HTATIP2

Oxidoreductase HTATIP2 is an enzyme that in humans is encoded by the HTATIP2 gene. It may be a metastasis suppressor.

HTATIP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BKA
Identifiers
Aliases	HTATIP2, CC3, SDR44U1, TIP30, HIV-1 Tat interactive protein 2
External IDs	OMIM: 605628; MGI: 1859271; HomoloGene: 4676; GeneCards: HTATIP2; OMA:HTATIP2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.1 Start 20,363,685 bp End 20,383,782 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 B4 Start 49,408,863 bp End 49,423,723 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa mucosa of colon duodenum mucosa of sigmoid colon islet of Langerhans sperm mucosa of transverse colon rectum monocyte epithelium of nasopharynx Top expressed in transitional epithelium of urinary bladder stroma of bone marrow epithelium of stomach duodenum lumbar spinal ganglion left lobe of liver pyloric antrum mucous cell of stomach seminal vesicula decidua More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity transcription coactivator activity protein binding Cellular component cytoplasm nuclear envelope membrane nucleus cytosol Biological process multicellular organism development regulation of transcription by RNA polymerase II cell differentiation viral process negative regulation of apoptotic process regulation of angiogenesis angiogenesis import into nucleus apoptotic process positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10553 53415 Ensembl ENSG00000109854 ENSMUSG00000039745 UniProt Q9BUP3 Q9Z2G9 RefSeq (mRNA) NM_006410 NM_001098520 NM_001098521 NM_001098522 NM_001098523 NM_001146049 NM_001146050 NM_001146052 NM_001146053 NM_016865 RefSeq (protein) NP_001091990 NP_001091991 NP_001091992 NP_001091993 NP_006401 NP_001139521 NP_001139522 NP_001139524 NP_001139525 NP_058561 Location (UCSC) Chr 11: 20.36 – 20.38 Mb Chr 7: 49.41 – 49.42 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Baker ME (1999). "TIP30, a cofactor for HIV-1 Tat-activated transcription, is homologous to short-chain dehydrogenases/reductases". Curr. Biol. 9 (13): R471. Bibcode:1999CBio....9.R471B. doi:10.1016/S0960-9822(99)80297-8. PMID 10395547. S2CID 7740085.
• Whitman S, Wang X, Shalaby R, Shtivelman E (2000). "Alternatively spliced products CC3 and TC3 have opposing effects on apoptosis". Mol. Cell. Biol. 20 (2): 583–93. doi:10.1128/MCB.20.2.583-593.2000. PMC 85138. PMID 10611237.
• Xiao H, Palhan V, Yang Y, Roeder RG (2000). "TIP30 has an intrinsic kinase activity required for up-regulation of a subset of apoptotic genes". EMBO J. 19 (5): 956–63. doi:10.1093/emboj/19.5.956. PMC 305635. PMID 10698937.
• Baker ME, Yan L, Pear MR (2000). "Three-dimensional model of human TIP30, a coactivator for HIV-1 Tat-activated transcription, and CC3, a protein associated with metastasis suppression". Cell. Mol. Life Sci. 57 (5): 851–8. doi:10.1007/s000180050047. PMC 11147082. PMID 10892349. S2CID 25141732.
• NicAmhlaoibh R, Shtivelman E (2001). "Metastasis suppressor CC3 inhibits angiogenic properties of tumor cells in vitro". Oncogene. 20 (2): 270–5. doi:10.1038/sj.onc.1204075. PMID 11313954.
• Ito M, Jiang C, Krumm K, Zhang X, Pecha J, Zhao J, Guo Y, Roeder RG, Xiao H (2004). "TIP30 deficiency increases susceptibility to tumorigenesis". Cancer Res. 63 (24): 8763–7. PMID 14695192.
• Jiang C, Ito M, Piening V, Bruck K, Roeder RG, Xiao H (2004). "TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription". J. Biol. Chem. 279 (26): 27781–9. doi:10.1074/jbc.M401809200. PMID 15073177.
• Tsutsumi S, Kamata N, Vokes TJ, Maruoka Y, Nakakuki K, Enomoto S, Omura K, Amagasa T, Nagayama M, Saito-Ohara F, Inazawa J, Moritani M, Yamaoka T, Inoue H, Itakura M (2004). "The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD)". Am. J. Hum. Genet. 74 (6): 1255–61. doi:10.1086/421527. PMC 1182089. PMID 15124103.
• King FW, Shtivelman E (2004). "Inhibition of nuclear import by the proapoptotic protein CC3". Mol. Cell. Biol. 24 (16): 7091–101. doi:10.1128/MCB.24.16.7091-7101.2004. PMC 479715. PMID 15282309.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Sun L, Feng S, Reséndiz JC, Lu X, Durante W, Kroll MH (2005). "Role of the Pyk2-MAP kinase-cPLA2 signaling pathway in shear-dependent platelet aggregation". Annals of Biomedical Engineering. 32 (9): 1193–201. doi:10.1114/B:ABME.0000039353.97347.28. PMID 15493507. S2CID 31410967.
• Shi M, Zhang X, Wang P, Zhang HW, Zhang BH, Wu MC (2005). "TIP30 regulates apoptosis-related genes in its apoptotic signal transduction pathway". World J. Gastroenterol. 11 (2): 221–7. doi:10.3748/wjg.v11.i2.221. PMC 4205406. PMID 15633220.
• El Omari K, Bird LE, Nichols CE, Ren J, Stammers DK (2005). "Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor". J. Biol. Chem. 280 (18): 18229–36. doi:10.1074/jbc.M501113200. PMID 15728189.
• Caldwell RL, Lane KB, Shepherd VL (2006). "HIV-1 Tat interaction with cyclin T1 represses mannose receptor and the bone morphogenetic protein receptor-2 transcription". Arch. Biochem. Biophys. 449 (1–2): 27–33. doi:10.1016/j.abb.2006.02.020. PMID 16615932.