Protein Hook homolog 3 is a protein that in humans is encoded by the HOOK3 gene.[5][6]

HOOK3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHOOK3, HK3, hook microtubule-tethering protein 3, hook microtubule tethering protein 3
External IDsOMIM: 607825; MGI: 2443554; HomoloGene: 13022; GeneCards: HOOK3; OMA:HOOK3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032410

NM_207659

RefSeq (protein)

NP_115786

NP_997542

Location (UCSC)Chr 8: 42.9 – 43.03 MbChr 8: 26.51 – 26.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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Hook proteins are cytosolic coiled coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168172Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037234Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kramer H, Phistry M (Mar 1999). "Genetic analysis of hook, a gene required for endocytic trafficking in drosophila". Genetics. 151 (2): 675–84. doi:10.1093/genetics/151.2.675. PMC 1460498. PMID 9927460.
  6. ^ a b "Entrez Gene: HOOK3 hook homolog 3 (Drosophila)".

Further reading

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