HOOK3

Protein Hook homolog 3 is a protein that in humans is encoded by the HOOK3 gene.

HOOK3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5J8E
Identifiers
Aliases	HOOK3, HK3, hook microtubule-tethering protein 3, hook microtubule tethering protein 3
External IDs	OMIM: 607825 MGI: 2443554 HomoloGene: 13022 GeneCards: HOOK3
Gene location (Human) Chr. Chromosome 8 (human) Band 8p11.21 Start 42,896,946 bp End 43,030,535 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 A2 Start 26,511,449 bp End 26,609,252 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon sural nerve pancreatic epithelial cell corpus callosum endothelial cell internal globus pallidus deltoid muscle tibialis anterior muscle vastus lateralis muscle visceral pleura Top expressed in otolith organ utricle knee joint tibialis anterior muscle hand triceps brachii muscle vastus lateralis muscle foot triceps surae gastrocnemius muscle More reference expression data BioGPS n/a
Gene ontology Molecular function microtubule binding protein binding identical protein binding dynein light intermediate chain binding dynactin binding dynein light chain binding dynein intermediate chain binding Cellular component HOPS complex FHF complex cis-Golgi network centriolar satellite microtubule cytoskeleton cytosol pericentriolar material cytoplasm Golgi apparatus centrosome Biological process endosome to lysosome transport endosome organization neuronal stem cell population maintenance Golgi localization early endosome to late endosome transport cytoplasmic microtubule organization protein transport lysosome organization microtubule anchoring at centrosome interkinetic nuclear migration negative regulation of neurogenesis protein localization to centrosome cytoskeleton-dependent intracellular transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84376 320191 Ensembl ENSG00000168172 ENSMUSG00000037234 UniProt Q86VS8 Q8BUK6 RefSeq (mRNA) NM_032410 NM_207659 RefSeq (protein) NP_115786 NP_997542 Location (UCSC) Chr 8: 42.9 – 43.03 Mb Chr 8: 26.51 – 26.61 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

Hook proteins are cytosolic coiled coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.

Further reading

• Walenta JH, Didier AJ, Liu X, Krämer H (2001). "The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins". J. Cell Biol. 152 (5): 923–34. doi:10.1083/jcb.152.5.923. PMC 2198811. PMID 11238449.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shotland Y, Krämer H, Groisman EA (2003). "The Salmonella SpiC protein targets the mammalian Hook3 protein function to alter cellular trafficking". Mol. Microbiol. 49 (6): 1565–76. doi:10.1046/j.1365-2958.2003.03668.x. PMID 12950921. S2CID 30972454.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Kaiser F, Kaufmann SH, Zerrahn J (2004). "IIGP, a member of the IFN inducible and microbial defense mediating 47 kDa GTPase family, interacts with the microtubule binding protein hook3". J. Cell Sci. 117 (Pt 9): 1747–56. doi:10.1242/jcs.01039. PMID 15075236. S2CID 294834.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Simpson F, Martin S, Evans TM, et al. (2005). "A novel hook-related protein family and the characterization of hook-related protein 1". Traffic. 6 (6): 442–58. doi:10.1111/j.1600-0854.2005.00289.x. PMID 15882442. S2CID 25389776.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Sano H, Ishino M, Krämer H, et al. (2007). "The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A." J. Biol. Chem. 282 (11): 7973–81. doi:10.1074/jbc.M611537200. PMID 17237231.
• Ciampi R, Giordano TJ, Wikenheiser-Brokamp K, et al. (2007). "HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma". Endocr. Relat. Cancer. 14 (2): 445–52. doi:10.1677/ERC-07-0039. PMID 17639057.