HMOX1 (heme oxygenase 1 gene) is a human gene that encodes for the enzyme heme oxygenase 1 (EC 1.14.99.3). Heme oxygenase (abbreviated HMOX or HO) mediates the first step of heme catabolism, it cleaves heme to form biliverdin.

HMOX1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHMOX1, HMOX1D, HO-1, HSP32, bK286B10, heme oxygenase 1
External IDsOMIM: 141250; MGI: 96163; HomoloGene: 31075; GeneCards: HMOX1; OMA:HMOX1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002133

NM_010442

RefSeq (protein)

NP_002124

NP_034572

Location (UCSC)Chr 22: 35.38 – 35.39 MbChr 8: 75.82 – 75.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The HMOX gene is located on the long (q) arm of chromosome 22 at position 12.3, from base pair 34,101,636 to base pair 34,114,748.

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Heme oxygenase

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Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, carbon monoxide, and ferrous iron.[5] The biliverdin is subsequently converted to bilirubin by biliverdin reductase. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family.[6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100292Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005413Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lehninger's Principles of Biochemistry, 5th Edition. New York: W.H. Freeman and Company. 2008. pp. 876. ISBN 978-0-7167-7108-1.
  6. ^ "Entrez Gene: HMOX1 heme oxygenase (decycling) 1".

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: P09601 (Heme oxygenase 1) at the PDBe-KB.