HMOX1 (heme oxygenase 1 gene) is a human gene that encodes for the enzyme heme oxygenase 1 (EC 1.14.99.3). Heme oxygenase (abbreviated HMOX or HO) mediates the first step of heme catabolism, it cleaves heme to form biliverdin.

HMOX1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHMOX1, HMOX1D, HO-1, HSP32, bK286B10, heme oxygenase 1
External IDsOMIM: 141250 MGI: 96163 HomoloGene: 31075 GeneCards: HMOX1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002133

NM_010442

RefSeq (protein)

NP_002124

NP_034572

Location (UCSC)Chr 22: 35.38 – 35.39 MbChr 8: 75.82 – 75.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The HMOX gene is located on the long (q) arm of chromosome 22 at position 12.3, from base pair 34,101,636 to base pair 34,114,748.

Related conditionsEdit

Heme oxygenaseEdit

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, carbon monoxide, and ferrous iron.[5] The biliverdin is subsequently converted to bilirubin by biliverdin reductase. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family.[6]

See alsoEdit

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100292 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005413 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lehninger's Principles of Biochemistry, 5th Edition. New York: W.H. Freeman and Company. 2008. pp. 876. ISBN 978-0-7167-7108-1.
  6. ^ "Entrez Gene: HMOX1 heme oxygenase (decycling) 1".

Further readingEdit

External linksEdit

  • Overview of all the structural information available in the PDB for UniProt: P09601 (Heme oxygenase 1) at the PDBe-KB.