High mobility group nucleosome-binding domain-containing protein 3 is a protein that in humans is encoded by the HMGN3 gene.[3][4][5]

AliasesHMGN3, PNAS-25, TRIP7, PNAS-24, high mobility group nucleosomal binding domain 3
External IDsOMIM: 604502 HomoloGene: 130417 GeneCards: HMGN3
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for HMGN3
Genomic location for HMGN3
Band6q14.1Start79,201,245 bp[1]
End79,234,738 bp[1]
RNA expression pattern
PBB GE HMGN3 209377 s at fs.png
More reference expression data
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC)Chr 6: 79.2 – 79.23 Mbn/a
PubMed search[2]n/a
View/Edit Human

Thyroid hormone receptors are hormone-dependent transcription factors that regulate expression of a variety of specific target genes. The protein encoded by this gene binds thyroid hormone receptor beta, but only in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Two transcript variants encoding different isoforms have been found for this gene.[5]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118418 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (Jul 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol Endocrinol. 9 (2): 243–54. doi:10.1210/me.9.2.243. PMID 7776974.
  4. ^ West KL, Ito Y, Birger Y, Postnikov Y, Shirakawa H, Bustin M (Jul 2001). "HMGN3a and HMGN3b, two protein isoforms with a tissue-specific expression pattern, expand the cellular repertoire of nucleosome-binding proteins". J Biol Chem. 276 (28): 25959–69. doi:10.1074/jbc.M101692200. PMID 11356838.
  5. ^ a b "Entrez Gene: HMGN3 high mobility group nucleosomal binding domain 3".

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