Non-histone chromosomal protein HMG-14 is a protein that in humans is encoded by the HMGN1 gene.[4][5][6]

AliasesHMGN1, HMG14, high mobility group nucleosome binding domain 1
External IDsOMIM: 163920 MGI: 96120 HomoloGene: 3643 GeneCards: HMGN1
Gene location (Human)
Chromosome 21 (human)
Chr.Chromosome 21 (human)[1]
Chromosome 21 (human)
Genomic location for HMGN1
Genomic location for HMGN1
Band21q22.2Start39,342,315 bp[1]
End39,349,647 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 21: 39.34 – 39.35 Mbn/a
PubMed search[2][3]
View/Edit HumanView/Edit Mouse


Chromosomal protein HMG14 and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation.[7] Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.[6]


HMGN1 has been shown to interact with YWHAZ.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000205581 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Landsman D, Srikantha T, Westermann R, Bustin M (Dec 1986). "Chromosomal protein HMG-14. Complete human cDNA sequence and evidence for a multigene family". The Journal of Biological Chemistry. 261 (34): 16082–6. PMID 3782107.
  5. ^ Landsman D, McBride OW, Soares N, Crippa MP, Srikantha T, Bustin M (Feb 1989). "Chromosomal protein HMG-14. Identification, characterization, and chromosome localization of a functional gene from the large human multigene family". The Journal of Biological Chemistry. 264 (6): 3421–7. PMID 2563381.
  6. ^ a b "Entrez Gene: HMGN1 high-mobility group nucleosome binding domain 1".
  7. ^ Martínez de Paz A, Ausió J (2016). "HMGNs: The enhancer charmers". BioEssays. 38 (3): 226–31. doi:10.1002/bies.201500157. PMID 26709929.
  8. ^ Prymakowska-Bosak M, Hock R, Catez F, Lim JH, Birger Y, Shirakawa H, Lee K, Bustin M (Oct 2002). "Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteins". Molecular and Cellular Biology. 22 (19): 6809–19. doi:10.1128/MCB.22.19.6809-6819.2002. PMC 134047. PMID 12215538.

Further readingEdit