HDO may refer to:
- Hispanic Democratic Organization, United States, a PAC
- Hydrodeoxygenation, removing oxygen from compounds
- Semiheavy water, replacing hydrogen-1 with deuterium
- South Texas Regional Airport at Hondo, United States
- Hilversumsche Draadlooze Omroep, original name for Dutch broadcaster AVRO
This disambiguation page lists articles associated with the title HDO.
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