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Grapevine fanleaf virus

Grapevine fanleaf virus (GFLV) is a plant pathogenic virus of the family Secoviridae. It infects grapevines, causing chlorosis of the leaves and lowering the fruit quality.[2] Because of its effect on grape yield, GFLV is a pathogen of commercial importance. It is transmitted via a nematode vector, Xiphinema index.[3] This nematode acquires the virus through feeding on roots of an infected plant, and passes it on in the same manner.

Grapevine fanleaf virus (GFLV)
Crystal structure of Grapevine Fanleaf Virus capsid. PDB entry 2y26[1]
Virus classification
Group IV ((+)ssRNA)
Grapevine fanleaf virus
  • grapevine arricciamento virus
  • grapevine court noué virus
  • grapevine infectious degeneration virus
  • grapevine Reisigkrankheit virus
  • grapevine roncet virus
  • grapevine urticado virus

The virus has an RNA genome contained on two RNA molecules, each of which is covalently attached to a small protein (the viral genome-linked protein, VPg) at the 5' end.[2] Each RNA encodes a single open reading frame, coding for a polyprotein. The longer polyprotein (the product of RNA1) is cleaved into five functional proteins, including the viral RNA polymerase[4] and the shorter (from RNA2) is cleaved into three proteins. The coat protein derives from RNA2[5] and forms the icosahedral capsid of 60 identical protein subunits.[1]

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  1. ^ a b Schellenberger, P.; Sauter, C.; Lorber, B.; Bron, P.; Trapani, S.; Bergdoll, M.; Marmonier, A. L.; Schmitt-Keichinger, C.; Lemaire, O.; Demangeat, G. R.; Ritzenthaler, C. (2011). Nagy, Peter D, ed. "Structural Insights into Viral Determinants of Nematode Mediated Grapevine fanleaf virus Transmission". PLoS Pathogens. 7 (5): e1002034. doi:10.1371/journal.ppat.1002034. PMC 3098200. PMID 21625570.
  2. ^ Andret-Link, P.; Schmitt-Keichinger, C.; Demangeat, G. R.; Komar, V. R.; Fuchs, M. (2004). "The specific transmission of Grapevine fanleaf virus by its nematode vector Xiphinema index is solely determined by the viral coat protein". Virology. 320 (1): 12–22. doi:10.1016/j.virol.2003.11.022. PMID 15003859.
  3. ^ Ritzenthaler, C.; Viry, M.; Pinck, M.; Margis, R.; Fuchs, M.; Pinck, L. (1991). "Complete nucleotide sequence and genetic organization of grapevine fanleaf nepovirus RNA1". The Journal of General Virology. 72 ( Pt 10) (10): 2357–2365. doi:10.1099/0022-1317-72-10-2357. PMID 1655953.
  4. ^ Serghini, M. A.; Fuchs, M.; Pinck, M.; Reinbolt, J.; Walter, B.; Pinck, L. (1990). "RNA2 of grapevine fanleaf virus: Sequence analysis and coat protein cistron location". The Journal of General Virology. 71 ( Pt 7) (7): 1433–1441. doi:10.1099/0022-1317-71-7-1433. PMID 2374004.