Glycerophosphocholine cholinephosphodiesterase

The enzyme glycerophosphocholine cholinephosphodiesterase (EC 3.1.4.38) is an enzyme that catalyzes the reaction

glycerophosphocholine cholinephosphodiesterase
Identifiers
EC no.3.1.4.38
CAS no.60063-78-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
sn-glycero-3-phosphocholine + H2O = glycerol + phosphocholine

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name is sn-glycero-3-phosphocholine cholinephosphohydrolase. This enzyme is also called L-3-glycerylphosphinicocholine cholinephosphohydrolase.

Structural studies

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As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1WRA.

References

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  • Abra RM, Quinn PJ (1975). "A novel pathway for phosphatidylcholine catabolism in rat brain homogenates". Biochim. Biophys. Acta. 380 (3): 436–41. doi:10.1016/0005-2760(75)90111-3. PMID 166661.