Glutathione gamma-glutamylcysteinyltransferase

In enzymology, a glutathione gamma-glutamylcysteinyltransferase (EC 2.3.2.15) is an enzyme that catalyzes the chemical reaction

glutathione gamma-glutamylcysteinyltransferase
Identifiers
EC no.2.3.2.15
CAS no.125390-02-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins
glutathione + [Glu(-Cys)]n-Gly Gly + [Glu(-Cys)]n+1-Gly

Thus, the two substrates of this enzyme are glutathione and [Glu(-Cys)]n-Gly, whereas its two products are Gly and [Glu(-Cys)]n+1-Gly.

This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme class is glutathione:poly(4-glutamyl-cysteinyl)glycine 4-glutamylcysteinyltransferase. Other names in common use include phytochelatin synthase, and gamma-glutamylcysteine dipeptidyl transpeptidase.

Structural studies

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As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2BTW and 2BU3.

References

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  • Grill E, Loffler S, Winnacker E-L, Zenk MH (1989). "Phytochelatins, the heavy-metal-binding peptides of plants, are synthesized from glutathione by a specific gamma-glutamylcysteine dipeptidyl transpeptidase (phytochelatin synthase)". Proc. Natl. Acad. Sci. USA. 86 (18): 6838–6842. Bibcode:1989PNAS...86.6838G. doi:10.1073/pnas.86.18.6838. PMC 297945. PMID 16594069.