Glucokinase regulator is a protein that in humans is encoded by the GCKR gene. [5]

GCKR
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGCKR, FGQTL5, GKRP, glucokinase (hexokinase 4) regulator, glucokinase regulator
External IDsOMIM: 600842; MGI: 1096345; HomoloGene: 1139; GeneCards: GCKR; OMA:GCKR - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001486

NM_144909
NM_001374741

RefSeq (protein)

NP_001477

NP_659158
NP_001361670

Location (UCSC)Chr 2: 27.5 – 27.52 MbChr 5: 31.45 – 31.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene encodes a protein belonging to the GCKR subfamily of the SIS (sugar isomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000084734Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059434Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Glucokinase regulator". Retrieved 2018-09-21.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.