In Italy, another clergyman member of this family was cardinal Innico d'Avalos d'Aragona.
He studied under his uncle, Hernando de Talavera, Archbishop of Granada. He then attended the University of Paris, receiving a licentiate in theology, and then studied theology at the University of Salamanca.
He lived in Baeza, Alcaraz, and Guadix. On August 4, 1509, he became a fellow of the Colegio de Santa Cruz at the University of Valladolid, later becoming a professor there. In 1517, he became lector in theology at Santa María de Guadalupe. He was also a canon of the cathedral chapter of the Cathedral of Murcia and of Cartagena Cathedral.
On November 14, 1524, he was elected Bishop of Guadix y Baza. Charles I of Spain and Alonso Manrique de Lara, the Grand Inquisitor of Spain, named him commissary general of the Spanish Inquisition in Valencia in 1525. He was promoted to the metropolitan see of Granada on January 22, 1529. In that capacity, he played a role in founding the University of Granada. On March 29, 1542, he was transferred to the metropolitan see of Compostela.
Pope Paul III made him a cardinal priest in the consistory of December 19, 1544. He died before receiving the red hat or a titular church. King Charles I nominated him to be Archbishop of Toledo but he died before he was preconized by the pope.