G2 and S phase-expressed protein 1 is an enzyme that in humans is encoded by the GTSE1 gene.[5][6][7][8]

GTSE1
Identifiers
AliasesGTSE1, B99, G2 and S-phase expressed 1
External IDsOMIM: 607477; MGI: 1352755; HomoloGene: 8489; GeneCards: GTSE1; OMA:GTSE1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016426

NM_001168672
NM_013882

RefSeq (protein)

NP_057510

NP_001162143
NP_038910

Location (UCSC)Chr 22: 46.3 – 46.33 MbChr 15: 85.74 – 85.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000075218Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022385Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Monte M, Collavin L, Lazarevic D, Utrera R, Dragani TA, Schneider C (Oct 2000). "Cloning, chromosome mapping and functional characterization of a human homologue of murine gtse-1 (B99) gene". Gene. 254 (1–2): 229–36. doi:10.1016/S0378-1119(00)00260-2. PMID 10974554.
  6. ^ Collavin L, Monte M, Verardo R, Pfleger C, Schneider C (Oct 2000). "Cell-cycle regulation of the p53-inducible gene B99". FEBS Lett. 481 (1): 57–62. doi:10.1016/S0014-5793(00)01969-4. PMID 10984615.
  7. ^ Monte M, Benetti R, Buscemi G, Sandy P, Del Sal G, Schneider C (Aug 2003). "The cell cycle-regulated protein human GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function". J Biol Chem. 278 (32): 30356–64. doi:10.1074/jbc.M302902200. PMID 12750368.
  8. ^ a b "Entrez Gene: GTSE1 G-2 and S-phase expressed 1".

Further reading

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