GSTT2

GSTT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4MPF
Identifiers
Aliases	GSTT2, GSTT2B, glutathione S-transferase theta 2 (gene/pseudogene)
External IDs	OMIM: 600437 MGI: 106188 HomoloGene: 37358 GeneCards: GSTT2
Gene location (Human)
Chr.	Chromosome 22 (human)
End	23,983,915 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	75,673,258 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; superior frontal gyrus; ; prefrontal cortex; ; fundus; ; left adrenal gland; ; ascending aorta; ; left coronary artery; ; prostate; ; mucosa of large intestine; ; renal cortex;
	Top expressed in
	kidney; ; proximal tubule; ; duodenum; ; left lobe of liver; ; spermatocyte; ; yolk sac; ; cervix; ; saccule; ; white adipose tissue; ; jejunum;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; glutathione transferase activity;
Cellular component	extracellular exosome; cytoplasm;
Biological process	glutathione metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	2953
	14872
	ENSG00000099984; ENSG00000277897
	ENSMUSG00000033318
	P0CG29
	Q61133
	NM_000854; NM_001302670
	NM_010361
	NP_000845; NP_001289599
	NP_034491
	Wikidata
View/Edit Human	View/Edit Mouse

Glutathione S-transferase theta-2 is an enzyme that in humans is encoded by the GSTT2 gene.^[5]^[6]^[7]

Glutathione S-transferase (GSTs) theta 2 (GSTT2) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: Alpha, Mu, Pi, Theta, and Zeta. The theta class members GSTT1 and GSTT2 share 55% amino acid sequence identity and both are thought to have an important role in human carcinogenesis. The theta genes have a similar structure, being composed of five exons with identical exon/intron boundaries.^[7]

References edit

^ ^a ^b ^c ENSG00000277897 GRCh38: Ensembl release 89: ENSG00000099984, ENSG00000277897 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033318 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tan KL, Webb GC, Baker RT, Board PG (Jul 1995). "Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22". Genomics. 25 (2): 381–7. doi:10.1016/0888-7543(95)80037-M. PMID 7789971.
^ Coggan M, Whitbread L, Whittington A, Board P (Nov 1998). "Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex". Biochem J. 334 (3): 617–23. doi:10.1042/bj3340617. PMC 1219731. PMID 9729470.
^ ^a ^b "Entrez Gene: GSTT2 glutathione S-transferase theta 2".

Further reading edit

Hussey AJ, Hayes JD (1992). "Characterization of a human class-Theta glutathione S-transferase with activity towards 1-menaphthyl sulphate". Biochem. J. 286 (3): 929–35. doi:10.1042/bj2860929. PMC 1132992. PMID 1417752.
Whittington AT, Webb GC, Baker RT, Board PG (1996). "Characterization of a cDNA and gene encoding the mouse theta class glutathione transferase mGSTT2 and its localization to chromosome 10B5-C1". Genomics. 33 (1): 105–11. doi:10.1006/geno.1996.0165. PMID 8617493.
Webb G, Vaska V, Coggan M, Board P (1996). "Chromosomal localization of the gene for the human theta class glutathione transferase (GSTT1)". Genomics. 33 (1): 121–3. doi:10.1006/geno.1996.0167. PMID 8617495.
Mainwaring GW, Williams SM, Foster JR, et al. (1996). "The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human". Biochem. J. 318 (1): 297–303. doi:10.1042/bj3180297. PMC 1217621. PMID 8761485.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Chelvanayagam G, Wilce MC, Parker MW, et al. (1997). "Homology model for the human GSTT2 Theta class glutathione transferase". Proteins. 27 (1): 118–30. doi:10.1002/(SICI)1097-0134(199701)27:1<118::AID-PROT12>3.0.CO;2-Q. PMID 9037717. S2CID 35684018.
Rossjohn J, McKinstry WJ, Oakley AJ, et al. (1998). "Human theta class glutathione transferase: the crystal structure reveals a sulfate-binding pocket within a buried active site". Structure. 6 (3): 309–22. doi:10.1016/S0969-2126(98)00034-3. PMID 9551553.
de Bruin WC, Wagenmans MJ, Board PG, Peters WH (1999). "Expression of glutathione S-transferase theta class isoenzymes in human colorectal and gastric cancers". Carcinogenesis. 20 (8): 1453–7. doi:10.1093/carcin/20.8.1453. PMID 10426791.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
de Bruin WC, Wagenmans MJ, Peters WH (2000). "Expression of glutathione S-transferase alpha, P1-1 and T1-1 in the human gastrointestinal tract". Jpn. J. Cancer Res. 91 (3): 310–6. doi:10.1111/j.1349-7006.2000.tb00946.x. PMC 5926361. PMID 10760690.
Sprenger R, Schlagenhaufer R, Kerb R, et al. (2001). "Characterization of the glutathione S-transferase GSTT1 deletion: discrimination of all genotypes by polymerase chain reaction indicates a trimodular genotype-phenotype correlation". Pharmacogenetics. 10 (6): 557–65. doi:10.1097/00008571-200008000-00009. PMID 10975610.
Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. Bibcode:2001Sci...291.1304V. doi:10.1126/science.1058040. PMID 11181995.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
De Maria F, Pedersen JZ, Caccuri AM, et al. (2004). "The specific interaction of dinitrosyl-diglutathionyl-iron complex, a natural NO carrier, with the glutathione transferase superfamily: suggestion for an evolutionary pressure in the direction of the storage of nitric oxide". J. Biol. Chem. 278 (43): 42283–93. doi:10.1074/jbc.M305568200. PMID 12871945.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Jang SG, Kim IJ, Kang HC, et al. (2007). "GSTT2 promoter polymorphisms and colorectal cancer risk". BMC Cancer. 7: 16. doi:10.1186/1471-2407-7-16. PMC 1793996. PMID 17250773.

This enzyme-related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000277897 GRCh38: Ensembl release 89: ENSG00000099984, ENSG00000277897 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033318 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7789971-5] Tan KL, Webb GC, Baker RT, Board PG (Jul 1995). "Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22". Genomics. 25 (2): 381–7. doi:10.1016/0888-7543(95)80037-M. PMID 7789971.

[pmid9729470-6] Coggan M, Whitbread L, Whittington A, Board P (Nov 1998). "Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex". Biochem J. 334 (3): 617–23. doi:10.1042/bj3340617. PMC 1219731. PMID 9729470.

[entrez-7] "Entrez Gene: GSTT2 glutathione S-transferase theta 2".

[5]

[6]

[7]

[1]

[2]

[3]

[4]