G-protein-signaling modulator 1 is a protein that in humans is encoded by the GPSM1 gene .[5] [6] [7]
G proteins propagate intracellular signals initiated by G protein-coupled receptors. GPSM1, a receptor-independent activator of G protein signaling, is one of several factors that influence the basal activity of G protein signaling systems (Pizzinat et al., 2001).[supplied by OMIM][7]
References
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^ a b c GRCh38: Ensembl release 89: ENSG00000160360 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026930 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Pizzinat N, Takesono A, Lanier SM (May 2001). "Identification of a truncated form of the G-protein regulator AGS3 in heart that lacks the tetratricopeptide repeat domains" . J Biol Chem . 276 (20): 16601–10. doi :10.1074/jbc.M007573200 PMID 11278352 . ^ Peterson YK, Bernard ML, Ma H, Hazard S III, Graber SG, Lanier SM (Nov 2000). "Stabilization of the GDP-bound conformation of Gialpha by a peptide derived from the G-protein regulatory motif of AGS3" . J Biol Chem . 275 (43): 33193–6. doi :10.1074/jbc.C000509200 PMID 10969064 . ^ a b "Entrez Gene: GPSM1 G-protein signalling modulator 1 (AGS3-like, C. elegans)" .
Further reading
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Natochin M, Lester B, Peterson YK, et al. (2001). "AGS3 inhibits GDP dissociation from galpha subunits of the Gi family and rhodopsin-dependent activation of transducin" . J. Biol. Chem . 275 (52): 40981–5. doi :10.1074/jbc.M006478200 PMID 11024022 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Pattingre S, De Vries L, Bauvy C, et al. (2003). "The G-protein regulator AGS3 controls an early event during macroautophagy in human intestinal HT-29 cells" . J. Biol. Chem . 278 (23): 20995–1002. doi :10.1074/jbc.M300917200 PMID 12642577 . Kaushik R, Yu F, Chia W, et al. (2004). "Subcellular Localization of LGN During Mitosis: Evidence for Its Cortical Localization in Mitotic Cell Culture Systems and Its Requirement for Normal Cell Cycle Progression" . Mol. Biol. Cell . 14 (8): 3144–55. doi :10.1091/mbc.E03-04-0212 . PMC 181556 PMID 12925752 . Adhikari A, Sprang SR (2004). "Thermodynamic characterization of the binding of activator of G protein signaling 3 (AGS3) and peptides derived from AGS3 with G alpha i1" . J. Biol. Chem . 278 (51): 51825–32. doi :10.1074/jbc.M306300200 PMID 14530282 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Du Q, Macara IG (2004). "Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins" . Cell . 119 (4): 503–16. doi :10.1016/j.cell.2004.10.028 PMID 15537540 . S2CID 12900159 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Izaki T, Kamakura S, Kohjima M, Sumimoto H (2006). "Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3". Biochem. Biophys. Res. Commun . 341 (4): 1001–6. doi :10.1016/j.bbrc.2006.01.050 . PMID 16458856 .
