G protein-coupled receptor family C group 6 member A (GPRC6A) is a protein that in humans is encoded by the GPRC6A gene.[5] This protein functions as a receptor of L-α-amino acids,[6] cations (e.g., calcium),[7] osteocalcin,[8] and steroids.[9] It is a membrane androgen receptor.

AliasesGPRC6A, GPCR, bA86F4.3, G protein-coupled receptor class C group 6 member A
External IDsOMIM: 613572 MGI: 2429498 HomoloGene: 17529 GeneCards: GPRC6A
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for GPRC6A
Genomic location for GPRC6A
Band6q22.1Start116,792,085 bp[1]
End116,829,037 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 6: 116.79 – 116.83 MbChr 10: 51.61 – 51.63 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Clinical significanceEdit

GPRC6A has also been linked to prostate cancer progression, and it has been shown to mediate rapid, non-genomic prostate cancer cell responses to testosterone.[10]

See alsoEdit


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173612 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019905 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: GPRC6A G protein-coupled receptor, family C, group 6, member A".
  6. ^ Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H (2005). "Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids". Mol. Pharmacol. 67 (3): 589–97. doi:10.1124/mol.104.007559. PMID 15576628. S2CID 469049.
  7. ^ Pi M, Faber P, Ekema G, Jackson PD, Ting A, Wang N, Fontilla-Poole M, Mays RW, Brunden KR, Harrington JJ, Quarles LD (December 2005). "Identification of a novel extracellular cation-sensing G-protein-coupled receptor". J. Biol. Chem. 280 (48): 40201–9. doi:10.1074/jbc.M505186200. PMC 1435382. PMID 16199532.
  8. ^ Pi M, Wu Y, Quarles LD (July 2011). "GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo". J. Bone Miner. Res. 26 (7): 1680–3. doi:10.1002/jbmr.390. PMC 5079536. PMID 21425331.
  9. ^ Pi M, Parrill AL, Quarles LD (December 2010). "GPRC6A mediates the non-genomic effects of steroids". J. Biol. Chem. 285 (51): 39953–64. doi:10.1074/jbc.M110.158063. PMC 3000977. PMID 20947496.
  10. ^ Pi M, Quarles LD (June 2011). "GPRC6A regulates prostate cancer progression". Prostate. 72 (4): 399–409. doi:10.1002/pros.21442. PMC 3183291. PMID 21681779.

Further readingEdit

External linksEdit