Glycoprotein hormone alpha-2 is a protein that in humans is encoded by the GPHA2 gene.[5][6]

GPHA2
Identifiers
AliasesGPHA2, A2, GPA2, ZSIG51, glycoprotein hormone alpha 2, glycoprotein hormone subunit alpha 2
External IDsOMIM: 609651; MGI: 2156541; HomoloGene: 15605; GeneCards: GPHA2; OMA:GPHA2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_130769

NM_130453

RefSeq (protein)

NP_570125

NP_569720

Location (UCSC)Chr 11: 64.93 – 64.94 MbChr 19: 6.28 – 6.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GPHA2 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002).[supplied by OMIM][6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000149735Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024784Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hsu SY, Nakabayashi K, Nishi S, Kumagai J, Kudo M, Sherwood OD, Hsueh AJ (Jan 2002). "Activation of orphan receptors by the hormone relaxin". Science. 295 (5555): 671–4. Bibcode:2002Sci...295..671H. doi:10.1126/science.1065654. PMID 11809971. S2CID 32693420.
  6. ^ a b "Entrez Gene: GPHA2 glycoprotein hormone alpha 2".

7. Z. Gong, W. Wang, K. El Omari, A. A. Lebedev, O. B. Clarke, W. A. Hendrickson, Crystal structure of LGR ligand alpha2/beta5 from Caenorhabditis elegans with implications for the evolution of glycoprotein hormones. Proc Natl Acad Sci U S A 120 (1), e2218630120 (2023). https://www.pnas.org/doi/10.1073/pnas.2218630120#

Further reading

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