GAS2

Growth arrest-specific protein 2 is a protein that in humans is encoded by the GAS2 gene.

GAS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1V5R
Identifiers
Aliases	GAS2, growth arrest specific 2, GAS-2
External IDs	OMIM: 602835 MGI: 95657 HomoloGene: 31301 GeneCards: GAS2
Gene location (Human) Chr. Chromosome 11 (human) Band 11p14.3 Start 22,625,509 bp End 22,813,001 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 B4|7 32.87 cM Start 51,511,763 bp End 51,644,723 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trigeminal ganglion liver sural nerve right lobe of liver islet of Langerhans Achilles tendon spinal ganglia body of pancreas hair follicle metanephric glomerulus Top expressed in stria vascularis proximal tubule utricle kidney hand cochlea saccule left lobe of liver spermatocyte condyle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule binding actin binding Cellular component cytoskeleton cytosol actin filament membrane cytoplasm Biological process cell cycle regulation of cell shape apoptotic process initiation of primordial ovarian follicle growth antral ovarian follicle growth regulation of Notch signaling pathway ovulation basement membrane organization microtubule cytoskeleton organization actin cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2620 14453 Ensembl ENSG00000148935 ENSMUSG00000030498 UniProt O43903 P11862 RefSeq (mRNA) NM_001143830 NM_005256 NM_177553 NM_001351224 NM_001391933 NM_001391934 NM_001391935 NM_001391936 NM_001391937 NM_008087 NM_001330607 NM_001330608 RefSeq (protein) NP_001137302 NP_005247 NP_808221 NP_001338153 NP_001317536 NP_001317537 NP_032113 Location (UCSC) Chr 11: 22.63 – 22.81 Mb Chr 7: 51.51 – 51.64 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.

Further reading

• Olson RE, Morello JA, Kieff ED (1975). "Antibiotic treatment of oral anaerobic infections". Journal of Oral Surgery. 33 (8): 619–21. PMID 1056466.
• Brancolini C, Bottega S, Schneider C (1992). "Gas2, a growth arrest-specific protein, is a component of the microfilament network system". J. Cell Biol. 117 (6): 1251–61. doi:10.1083/jcb.117.6.1251. PMC 2289493. PMID 1607387.
• Schneider C, King RM, Philipson L (1988). "Genes specifically expressed at growth arrest of mammalian cells". Cell. 54 (6): 787–93. doi:10.1016/S0092-8674(88)91065-3. PMID 3409319. S2CID 37196421.
• Sgorbissa A, Benetti R, Marzinotto S, et al. (2000). "Caspase-3 and caspase-7 but not caspase-6 cleave Gas2 in vitro: implications for microfilament reorganization during apoptosis". J. Cell Sci. 112 (23): 4475–82. doi:10.1242/jcs.112.23.4475. PMID 10564664.
• Benetti R, Del Sal G, Monte M, et al. (2001). "The death substrate Gas2 binds m-calpain and increases susceptibility to p53-dependent apoptosis". EMBO J. 20 (11): 2702–14. doi:10.1093/emboj/20.11.2702. PMC 125501. PMID 11387205.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tsutsumi S, Kamata N, Vokes TJ, et al. (2004). "The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD)". Am. J. Hum. Genet. 74 (6): 1255–61. doi:10.1086/421527. PMC 1182089. PMID 15124103.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Benetti R, Copetti T, Dell'Orso S, et al. (2005). "The calpain system is involved in the constitutive regulation of beta-catenin signaling functions". J. Biol. Chem. 280 (23): 22070–80. doi:10.1074/jbc.M501810200. PMID 15817486.