Gamma-guanidinobutyraldehyde dehydrogenase

In enzymology, a gamma-guanidinobutyraldehyde dehydrogenase (EC 1.2.1.54) is an enzyme that catalyzes the chemical reaction

gamma-guanidinobutyraldehyde dehydrogenase
Identifiers
EC no.1.2.1.54
CAS no.56831-75-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins
4-guanidinobutanal + NAD+ + H2O 4-guanidinobutanoate + NADH + 2 H+

The 3 substrates of this enzyme are 4-guanidinobutanal, NAD+, and H2O, whereas its 3 products are 4-guanidinobutanoate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-guanidinobutanal:NAD+ 1-oxidoreductase. Other names in common use include alpha-guanidinobutyraldehyde dehydrogenase, 4-guanidinobutyraldehyde dehydrogenase, and GBAL dehydrogenase. This enzyme participates in urea cycle and metabolism of amino groups.

References

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  • Yorifuji T, Koike K, Sakurai T, Yokoyama K (1986). "4-Aminobutyraldehyde and 4-guanidinobutyraldehyde dehydrogenases for arginine degradation in Pseudomonas putida". Agric. Biol. Chem. 50 (8): 2009–2016. doi:10.1271/bbb1961.50.2009.