|Died||14 September 1550 (aged 59–60)|
|Noble family||House of Valois|
|Spouse(s)||Francis II, Duke of Longueville|
Charles de Bourbon, Duke of Vendôme
|Father||René of Alençon|
|Mother||Margaret of Lorraine|
Her son Antoine, however, went on to marry Jeanne III of Navarre, born of the second marriage of Marguerite with Henry II of Navarre. The grandson of Françoise and Marguerite, Henry de Bourbon, would become King of France and Navarre.
In 1505, Françoise married Francis II, Duke of Longueville. They had 2 children:
- Jacques d'Orléans-Longueville (1511–1512), unmarried
- Renée d'Orléans-Longueville, Countess of Dunois (1508–1515), unmarried
- Louis de Bourbon (1514–1516), unmarried
- Marie de Bourbon (1515–1538), unmarried
- Marguerite de Bourbon (1516–1589), married 1538 Francis I of Cleves, Duke de Nevers (1516–1561)
- Antoine de Bourbon, Duke of Vendôme (1518 – 1562), married 1548 Jeanne III, Queen of Navarre.
- François de Bourbon, Count of Enghien (1519–1546), unmarried
- Madeleine de Bourbon, Abbess of Sainte Croix de Poitiers (1521–1561), unmarried
- Louis de Bourbon (1522–1525), unmarried
- Charles de Bourbon, Archbishop of Rouen (1523–1590), unmarried
- Catherine de Bourbon, Abbess of Soissons (1525–1594), unmarried
- Renée de Bourbon, Abbess of Chelles (1527–1583), unmarried
- Jean de Bourbon, Count of Soissons and Enghien (1528–1557), married 1557 his first cousin Marie, Duchess of Estouteville (1539–1601)
- Louis de Bourbon, Prince of Condé (7 May 1530 – 13 March 1569), married Eléonore de Roye
- Léonore de Bourbon, Abbess of Fontevraud (1532–1611), unmarried
- Potter 1995, p. 378.
- Potter, David (1995). Keen, Maurice (ed.). A History of France, 1460–1560: The Emergence of a Nation State. Macmillan.