Far upstream element-binding protein 1

Far upstream element-binding protein 1 is a protein that in humans is encoded by the FUBP1 gene.[5][6]

FUBP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFUBP1, FBP, FUBP, hDH V, far upstream element binding protein 1
External IDsOMIM: 603444; MGI: 1196294; HomoloGene: 48253; GeneCards: FUBP1; OMA:FUBP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001303433
NM_003902
NM_001376055
NM_001376056
NM_001376057

RefSeq (protein)

NP_001290362
NP_003893
NP_001362984
NP_001362985
NP_001362986

Location (UCSC)Chr 1: 77.94 – 77.98 MbChr 3: 151.92 – 151.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a ssDNA binding protein that activates the far upstream element (FUSE) of c-myc and stimulates expression of c-myc in undifferentiated cells. Regulation of FUSE by FUBP occurs through single-strand binding of FUBP to the non-coding strand. This protein has been shown to function as an ATP-dependent DNA helicase.[6]

Interactions

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Far upstream element-binding protein 1 has been shown to interact with MAPK14[7] and SMN1.[8]

Clinical Significance

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FUBP1 gene deletion forms part of the 1p/19q codeletion mutation seen in oligodendroglioma, a form of primary brain tumour.[9] CIC gene is also lost in the 1p/19q codeletion mutation.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162613Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028034Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Duncan R, Bazar L, Michelotti G, Tomonaga T, Krutzsch H, Avigan M, Levens D (April 1994). "A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif". Genes Dev. 8 (4): 465–80. doi:10.1101/gad.8.4.465. PMID 8125259.
  6. ^ a b "Entrez Gene: FUBP1 far upstream element (FUSE) binding protein 1".
  7. ^ Kim, Min Jung; Park Bum-Joon; Kang Young-Sun; Kim Hyoung June; Park Jae-Hyun; Kang Jung Woo; Lee Sang Won; Han Jung Min; Lee Han-Woong; Kim Sunghoon (July 2003). "Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation". Nat. Genet. 34 (3). United States: 330–6. doi:10.1038/ng1182. ISSN 1061-4036. PMID 12819782. S2CID 41006480.
  8. ^ Williams, B Y; Hamilton S L; Sarkar H K (March 2000). "The survival motor neuron protein interacts with the transactivator FUSE binding protein from human fetal brain". FEBS Lett. 470 (2). NETHERLANDS: 207–10. doi:10.1016/S0014-5793(00)01320-X. ISSN 0014-5793. PMID 10734235. S2CID 28330997.
  9. ^ Weller, Michael (8 December 2020). "EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood". Nature Reviews. Clinical Oncology. 18 (3): 170–186. doi:10.1038/s41571-020-00447-z. PMC 7904519. PMID 33293629.

Further reading

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