Formin-like protein 1 is a protein that in humans is encoded by the FMNL1 gene.[5][6]

FMNL1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFMNL1, C17orf1, C17orf1B, FHOD4, FMNL, KW-13, formin like 1
External IDsOMIM: 604656; MGI: 1888994; HomoloGene: 136798; GeneCards: FMNL1; OMA:FMNL1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005892

NM_001077698
NM_019679

RefSeq (protein)

NP_005883

Location (UCSC)Chr 17: 45.22 – 45.25 MbChr 11: 103.06 – 103.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not been determined.[6]

Interactions

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FMNL1 has been shown to interact with Profilin 1,[7] PFN2[7] and RAC1.[7]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184922Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055805Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Aronsson FC, Magnusson P, Andersson B, Karsten SL, Shibasaki Y, Lendon CL, Goate AM, Brookes AJ (November 1998). "The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17". Hum Genet. 103 (3): 340–345. doi:10.1007/s004390050827. PMID 9799091. S2CID 11305597.
  6. ^ a b "Entrez Gene: FMNL1 formin-like 1".
  7. ^ a b c Yayoshi-Yamamoto, S; Taniuchi I; Watanabe T (September 2000). "FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages". Mol. Cell. Biol. 20 (18). UNITED STATES: 6872–6881. doi:10.1128/MCB.20.18.6872-6881.2000. ISSN 0270-7306. PMC 86228. PMID 10958683.

Further reading

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