Leucine-rich repeat transmembrane protein FLRT3 is a protein that in humans is encoded by the FLRT3 gene.[5][6]

FLRT3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFLRT3, HH21, fibronectin leucine rich transmembrane protein 3
External IDsOMIM: 604808; MGI: 1918686; HomoloGene: 8322; GeneCards: FLRT3; OMA:FLRT3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013281
NM_198391

NM_001172160
NM_178382

RefSeq (protein)

NP_037413
NP_938205

NP_001165631
NP_848469

Location (UCSC)Chr 20: 14.32 – 14.34 MbChr 2: 140.49 – 140.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FLRT1, FLRT2 and FLRT3 are members of the fibronectin leucine rich transmembrane protein (FLRT) family. They may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. FLRT3 shares 55% amino acid sequence identity with FLRT1 and 44% identity with FLRT2. FLRT3 is expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.[6]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125848Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051379Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lacy SE, Bonnemann CG, Buzney EA, Kunkel LM (Mar 2000). "Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins". Genomics. 62 (3): 417–26. doi:10.1006/geno.1999.6033. PMID 10644439.
  6. ^ a b "Entrez Gene: FLRT3 fibronectin leucine rich transmembrane protein 3".

Further reading

edit