Protein flightless-1 homolog is a protein that in humans is encoded by the FLII gene.[5][6]

FLII
Identifiers
AliasesFLII, FLI, FLIL, Fli1, actin remodeling protein, FLII actin remodeling protein
External IDsOMIM: 600362; MGI: 1342286; HomoloGene: 11092; GeneCards: FLII; OMA:FLII - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001256264
NM_001256265
NM_002018

NM_022009
NM_001302207

RefSeq (protein)

NP_001243193
NP_001243194
NP_002009

NP_001289136
NP_071292

Location (UCSC)Chr 17: 18.24 – 18.26 MbChr 11: 60.6 – 60.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain.[7] The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17.[6]

Interactions

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FLII has been shown to interact with LRRFIP1[8][9] and TRAF interacting protein.[10]

References

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  1. ^ a b c ENSG00000284571 GRCh38: Ensembl release 89: ENSG00000177731, ENSG00000284571Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002812Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chen KS, Gunaratne PH, Hoheisel JD, Young IG, Miklos GL, Greenberg F, Shaffer LG, Campbell HD, Lupski JR (Feb 1995). "The human homologue of the Drosophila melanogaster flightless-I gene (flil) maps within the Smith-Magenis microdeletion critical region in 17p11.2". Am J Hum Genet. 56 (1): 175–82. PMC 1801336. PMID 7825574.
  6. ^ a b "Entrez Gene: FLII flightless I homolog (Drosophila)".
  7. ^ Ghoshdastider U, Popp D, Burtnick LD, Robinson RC (2013). "The expanding superfamily of gelsolin homology domain proteins". Cytoskeleton. 70 (11): 775–95. doi:10.1002/cm.21149. PMID 24155256. S2CID 205643538.
  8. ^ Liu, Y T; Yin H L (Apr 1998). "Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies". J. Biol. Chem. 273 (14): 7920–7. doi:10.1074/jbc.273.14.7920. ISSN 0021-9258. PMID 9525888.
  9. ^ Fong, K S; de Couet H G (Jun 1999). "Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system". Genomics. 58 (2): 146–57. doi:10.1006/geno.1999.5817. ISSN 0888-7543. PMID 10366446.
  10. ^ Wilson, S A; Brown E C; Kingsman A J; Kingsman S M (Aug 1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I". Nucleic Acids Res. 26 (15): 3460–7. doi:10.1093/nar/26.15.3460. ISSN 0305-1048. PMC 147727. PMID 9671805.

Further reading

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