Four and a half LIM domains protein 5 is a protein that in humans is encoded by the FHL5 gene.[5]

FHL5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFHL5, ACT, dJ393D12.2, 1700027G07Rik, FHL-5, four and a half LIM domains 5
External IDsOMIM: 605126; MGI: 1913192; HomoloGene: 23230; GeneCards: FHL5; OMA:FHL5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001170807
NM_020482
NM_001322466
NM_001322467

NM_021318
NM_001355498
NM_001379528

RefSeq (protein)

NP_001164278
NP_001309395
NP_001309396
NP_065228

NP_067293
NP_001342427
NP_001366457

Location (UCSC)Chr 6: 96.56 – 96.62 MbChr 4: 25.2 – 25.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene.[5]

Interactions

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FHL5 has been shown to interact with CREB1[6] and CAMP responsive element modulator.[6][7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112214Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028259Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: FHL5 four and a half LIM domains 5".
  6. ^ a b Fimia GM, De Cesare D, Sassone-Corsi P (November 2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Mol. Cell. Biol. 20 (22): 8613–22. doi:10.1128/MCB.20.22.8613-8622.2000. PMC 102166. PMID 11046156.
  7. ^ Fimia GM, De Cesare D, Sassone-Corsi P (March 1999). "CBP-independent activation of CREM and CREB by the LIM-only protein ACT". Nature. 398 (6723): 165–9. Bibcode:1999Natur.398..165F. doi:10.1038/18237. PMID 10086359. S2CID 4424908.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.