FOXF1 adjacent non-coding developmental regulatory RNA is a long non-coding RNA that in humans is encoded by the FENDRR gene. [3]

FENDRR
Identifiers
AliasesFENDRR, FOXF1-AS1, TCONS_00024240, lincFOXF1, onco-lncRNA-21, FOXF1 adjacent non-coding developmental regulatory RNA, FOXF1AS1
External IDsOMIM: 614975; GeneCards: FENDRR; OMA:FENDRR - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

n/a

Location (UCSC)Chr 16: 86.47 – 86.51 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Function

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This gene produces a spliced long non-coding RNA transcribed bidirectionally with FOXF1 on the opposite strand. A similar gene in mouse is essential for normal development of the heart and body wall. The encoded transcript is thought to act by binding to polycomb repressive complex 2 (PRC2) and/or TrxG/MLL complexes to promote the methylation of the promoters of target genes, thus reducing their expression. It has been suggested that this transcript may play a role in the progression of gastric cancer. Alternatively spliced transcript variants have been identified.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000268388Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Entrez Gene: FOXF1 adjacent non-coding developmental regulatory RNA". Retrieved 2016-11-10.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.