FCHO2

FCH domain only protein 2 is a protein that in humans is encoded by the FCHO2 gene.

FCHO2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2V0O
Identifiers
Aliases	FCHO2, FCH domain only 2, FCH and mu domain containing endocytic adaptor 2
External IDs	OMIM: 613438; MGI: 3505790; HomoloGene: 9030; GeneCards: FCHO2; OMA:FCHO2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q13.2 Start 72,956,041 bp End 73,090,522 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 D1 Start 98,859,911 bp End 98,951,957 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon tibialis anterior muscle jejunal mucosa lower lobe of lung oral cavity visceral pleura seminal vesicula palpebral conjunctiva duodenum superficial temporal artery Top expressed in interventricular septum superior cervical ganglion hand carotid body suprachiasmatic nucleus otolith organ intercostal muscle utricle pineal gland mammillary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylinositol-4,5-bisphosphate binding phosphatidylserine binding protein binding phosphatidylinositol binding identical protein binding phospholipid binding microtubule binding cytoskeletal protein binding tubulin binding Cellular component plasma membrane clathrin-coated pit membrane clathrin-coated vesicle cytosol presynaptic endocytic zone membrane cytoplasm cytoskeleton AP-2 adaptor complex Biological process membrane invagination protein localization to plasma membrane endocytosis clathrin coat assembly synaptic vesicle endocytosis membrane organization clathrin-dependent endocytosis plasma membrane tubulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 115548 218503 Ensembl ENSG00000157107 ENSMUSG00000041685 UniProt Q0JRZ9 Q3UQN2 RefSeq (mRNA) NM_138782 NM_001146032 NM_172591 RefSeq (protein) NP_001139504 NP_620137 NP_766179 Location (UCSC) Chr 5: 72.96 – 73.09 Mb Chr 13: 98.86 – 98.95 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Henne WM, Kent HM, Ford MG, Hegde BG, Daumke O, Butler PJ, Mittal R, Langen R, Evans PR, McMahon HT (Jul 2007). "Structure and analysis of FCHo2 F-BAR domain: a dimerizing and membrane recruitment module that effects membrane curvature". Structure. 15 (7): 839–52. doi:10.1016/j.str.2007.05.002. PMID 17540576.