High affinity immunoglobulin gamma Fc receptor I is a protein that in humans is encoded by the FCGR1A gene.[5][6][7]

FCGR1A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFCGR1A, CD64, CD64A, FCRI, IGFR1, Fc fragment of IgG receptor Ia
External IDsOMIM: 146760; MGI: 95498; HomoloGene: 475; GeneCards: FCGR1A; OMA:FCGR1A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000566

NM_010186

RefSeq (protein)

NP_034316

Location (UCSC)Chr 1: 149.78 – 149.79 MbChr 3: 96.19 – 96.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

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The FcgRI binds the Fc portion of IgG and causes activation of the host cell via an intercellular ITAM motif.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000150337Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015947Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Maresco DL, Chang E, Theil KS, Francke U, Anderson CL (September 1996). "The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21". Cytogenetics and Cell Genetics. 73 (3): 157–63. doi:10.1159/000134330. PMID 8697799.
  6. ^ Maresco DL, Blue LE, Culley LL, Kimberly RP, Anderson CL, Theil KS (November 1998). "Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1". Cytogenetics and Cell Genetics. 82 (1–2): 71–4. doi:10.1159/000015067. PMID 9763663. S2CID 20290009.
  7. ^ "Entrez Gene: FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)".
  8. ^ The function of Fcγ receptors in dendritic cells and macrophages Martin Guilliams Pierre Bruhns Yvan Saeys Hamida Hammad and Bart N. Lambrecht FEBRUARY 2014 | VOLUME 14 Nature Reviews Immunology

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: P12314 (Human High affinity immunoglobulin gamma Fc receptor I (FCGR1A)) at the PDBe-KB.