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Ezero follows the copper age cultures of the area (Karanovo VI culture, Gumelniţa culture, Kodzadjemen culture and Varna culture), after a settlement hiatus in Northern Bulgaria. It bears some relationship to the earlier Cernavodă III culture to the north. Some settlements were fortified.
The Ezero culture is interpreted as part of a larger Balkan-Danubian early Bronze Age complex, a horizon reaching from Troy Id-IIc into Central Europe, encompassing the Baden of the Carpathian Basin and the Coţofeni culture of Romania. According to Hermann Parzinger, there are also typological connections to Poliochne IIa-b and Sitagroi IV.
Agriculture is in evidence, along with domestic livestock. There is evidence of grape cultivation. Metallurgy was practiced.
Within the context of the Kurgan hypothesis, it would represent a fusion of native "Old European culture" and intrusive "Kurgan culture" elements. It could also represent an Anatolian-influenced culture, either coming from Anatolia (in Renfrew's hypothesis), or heading to Asia Minor.