Eupatorium perfoliatum

Eupatorium perfoliatum, known as common boneset or just boneset, is a North American perennial plant in the family Asteraceae. It is a common native to the Eastern United States and Canada, widespread from Nova Scotia to Florida, west as far as Texas, Nebraska, the Dakotas, and Manitoba.[3][4] It is also called agueweed, feverwort, or sweating-plant. It was introduced to American colonists by natives who used the plant for breaking fevers by means of heavy sweating. It is nearly always found in low, wet areas.[5]

Eupatorium perfoliatum
Eupatorium perfoliatum 001.JPG

Secure (NatureServe)[1]
Scientific classification edit
Kingdom: Plantae
Clade: Tracheophytes
Clade: Angiosperms
Clade: Eudicots
Clade: Asterids
Order: Asterales
Family: Asteraceae
Genus: Eupatorium
E. perfoliatum
Binomial name
Eupatorium perfoliatum
Eupatorium perfoliatum range map.jpg
  • Cunigunda perfoliata (L.) Lunell
  • Uncasia perfoliata (L.) Greene
  • Eupatorium chapmanii Small
  • Eupatorium connatum Michaux
  • Eupatorium salviifolium Sims
  • Eupatorium truncatum Muhl. ex Willd.
  • Eupatorium × truncatum Muhl. ex Willd.
  • Eupatorium cuneatum Engelm. ex Torr. & A.Gray
  • Uncasia cuneata (Engelm. ex Torr. & A.Gray) Greene
  • Uncasia truncata (Mühlenb. ex Willd.) Greene


E. perfoliatum can be recognized from its perfoliate leaves

Eupatorium perfoliatum grows up to 100 cm (39 inches) tall, with opposite, serrate leaves that clasp the stems (perfoliate).[5] The stem is hairy.[5] The plant produces dense clusters of tiny white flower heads held above the foliage. In Illinois, the plant blooms during late summer and early fall.[5] Its native habitats include damp prairies, bogs, and alluvial woods.[6]

Eupatorium perfoliatum can form hybrids with other species of the genus Eupatorium, for example Eupatorium serotinum.[3]

Phytochemistry and safetyEdit

Eupatorium perfoliatum leaves and roots contain mixed phytochemicals, including polysaccharides (containing xylose and glucuronic acid), tannins, volatile oil, sesquiterpene lactones, sterols, triterpenes, alkaloids, and various flavonoids, such as quercetin, kaempferol, and caffeic acid derivatives.[7][8] E. perfoliatum and several of its related species are listed on the Poisonous Plants Database of the US Food and Drug Administration,[9] with E. perfoliatum described as an "unapproved homeopathic medicine" with unknown safety by the US National Library of Medicine.[7][10]

Holistic health companies marketing fraudulent supplement products that contained E. perforliatum with claims of benefit against COVID-19 were warned by the US Food and Drug Administration in 2020 about making illegal health claims and scamming consumers from their money.[11]

Traditional medicineEdit

Eupatorium perfoliatum (also called boneset) was used in traditional medicine by Native Americans who applied extracts for fever and common colds.[7][8] Possible effects of E. perfoliatum for these uses remain undefined by adequate scientific research, and are unconfirmed by high-quality clinical research.[7][8] If consumed in large amounts, its tea made from leaves may cause diarrhea.[7]


  1. ^ "Eupatorium perfoliatum". NatureServe Explorer. NatureServe. Retrieved 2010-09-12.
  2. ^ "Eupatorium perfoliatum L.". The Global Compositae Checklist (GCC) – via The Plant List.
  3. ^ a b Siripun, Kunsiri Chaw; Schilling, Edward E. (2006). "Eupatorium perfoliatum". In Flora of North America Editorial Committee (ed.). Flora of North America North of Mexico (FNA). Vol. 21. New York and Oxford – via, Missouri Botanical Garden, St. Louis, MO & Harvard University Herbaria, Cambridge, MA.
  4. ^ "Eupatorium perfoliatum". County-level distribution map from the North American Plant Atlas (NAPA). Biota of North America Program (BONAP). 2014.
  5. ^ a b c d Hilty, John (24 October 2018). "Common Boneset". Illinois Wildflowers. Retrieved 6 September 2022.
  6. ^ "Lady Bird Johnson Wildflower Center - The University of Texas at Austin". Retrieved 2023-01-29.
  7. ^ a b c d e "Boneset (Eupatorium perfoliatum L.) Uses, Benefits and Dosage". 1 February 2019. Retrieved 4 March 2019.
  8. ^ a b c Hensel, Andreas; Maas, Mareike; Sendker, Jandirk; Lechtenberg, Matthias; Petereit, Frank; Deters, Alexandra; Schmidt, Thomas; Stark, Timo (2011). "Eupatorium perfoliatum L.: Phytochemistry, traditional use and current applications". Journal of Ethnopharmacology. 138 (3): 641–651. doi:10.1016/j.jep.2011.10.002. PMID 22004891.
  9. ^ "Flavonol-3-glucosides in 8 Eupatorium species; In: FDA Poisonous Plant Database". US Food and Drug Administration. 2019. Retrieved 4 March 2019.
  10. ^ "Eupatorium perfoliatum L." DailyMed, National Library of Medicine, US National Institutes of Health. 2019. Retrieved 4 March 2019.
  11. ^ "Fraudulent Coronavirus Disease 2019 (COVID-19) Products". US Food and Drug Administration. 7 April 2020. Retrieved 8 April 2020.

External linksEdit