Ectonucleoside triphosphate diphosphohydrolase 4

Ectonucleoside triphosphate diphosphohydrolase 4 is a protein that in humans is encoded by the ENTPD4 gene.

ENTPD4
Identifiers
Aliases	ENTPD4, LALP70, LAP70, LYSAL1, NTPDase-4, UDPase, ectonucleoside triphosphate diphosphohydrolase 4
External IDs	OMIM: 607577; MGI: 5435040; HomoloGene: 68421; GeneCards: ENTPD4; OMA:ENTPD4 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8p21.3 Start 23,385,783 bp End 23,457,695 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14 D2|14 Start 69,792,873 bp End 69,822,969 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 middle temporal gyrus tibia endothelial cell lateral nuclear group of thalamus postcentral gyrus Brodmann area 46 orbitofrontal cortex tonsil palpebral conjunctiva Top expressed in proximal tubule quadriceps femoris muscle spermatocyte adrenal gland skeletal muscle tissue human kidney right kidney muscle of thigh urinary bladder spermatid More reference expression data BioGPS n/a
Gene ontology Molecular function hydrolase activity uridine-diphosphatase activity nucleoside-diphosphatase activity nucleoside-triphosphatase activity Cellular component membrane cytoplasmic vesicle integral component of Golgi membrane Golgi apparatus autophagosome membrane integral component of membrane Golgi membrane integral component of autophagosome membrane Biological process UDP catabolic process nucleobase-containing small molecule catabolic process metabolism Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9583 100862375 Ensembl ENSG00000197217 ENSMUSG00000022066 UniProt Q9Y227 Q8NE73 Q9DBT4 RefSeq (mRNA) NM_004901 NM_001128930 NM_001359159 NM_001359160 RefSeq (protein) NP_001122402 NP_004892 NP_080450 NP_001347281 Location (UCSC) Chr 8: 23.39 – 23.46 Mb Chr 14: 69.79 – 69.82 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the apyrase protein family. Apyrases are enzymes that catalyze the hydrolysis of nucleotide diphosphates and triphosphates in a calcium or magnesium ion-dependent manner. The encoded protein is an endo-apyrase and may play a role in salvaging nucleotides from lysosomes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and these isoforms may differ in divalent cation dependence and substrate specificity. [provided by RefSeq, Sep 2011].

Further reading

• Biederbick A, Rösser R, Storre J, Elsässer HP (June 2004). "The VSFASSQQ motif confers calcium sensitivity to the intracellular apyrase LALP70". BMC Biochem. 5: 8. doi:10.1186/1471-2091-5-8. PMC 443525. PMID 15200686.
• Joslyn G, Ravindranathan A, Brush G, Schuckit M, White RL (May 2010). "Human variation in alcohol response is influenced by variation in neuronal signaling genes". Alcohol. Clin. Exp. Res. 34 (5): 800–12. doi:10.1111/j.1530-0277.2010.01152.x. PMID 20201926.
• Saito A, Fujikura-Ouchi Y, Ito C, Matsuoka H, Shimoda K, Akiyama K (January 2011). "An association study on polymorphisms in the PEA15, ENTPD4, and GAS2L1 genes and schizophrenia". Psychiatry Res. 185 (1–2): 9–15. doi:10.1016/j.psychres.2009.09.018. PMID 20537721. S2CID 23210085.
• Saito A, Fujikura-Ouchi Y, Ito C, Matsuoka H, Shimoda K, Akiyama K (January 2011). "An association study on polymorphisms in the PEA15, ENTPD4, and GAS2L1 genes and schizophrenia". Psychiatry Res. 185 (1–2): 9–15. doi:10.1016/j.psychres.2009.09.018. PMID 20537721. S2CID 23210085.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.