ERRFI1

ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ERRFI1 gene.

ERRFI1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RF9, 2RFD, 2RFE, 4I21, 4R3P, 4R3R, 4ZJV
Identifiers
Aliases	ERRFI1, GENE-33, MIG-6, MIG6, RALT, ERBB receptor feedback inhibitor 1
External IDs	OMIM: 608069 MGI: 1921405 HomoloGene: 10344 GeneCards: ERRFI1
Gene location (Human) Chr. Chromosome 1 (human) Band 1p36.23 Start 8,004,404 bp End 8,026,309 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 E2 Start 150,938,376 bp End 150,953,349 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas vena cava right lobe of liver tibialis anterior muscle gastric mucosa synovial joint ascending aorta synovial membrane pancreatic epithelial cell left uterine tube Top expressed in left lobe of liver gallbladder kidney right lung lobe left lung left lung lobe carotid body secondary oocyte utricle medullary collecting duct More reference expression data BioGPS n/a
Gene ontology Molecular function GTPase activator activity SH3 domain binding kinase binding protein binding protein kinase binding small GTPase binding Cellular component membrane extrinsic component of cytoplasmic side of plasma membrane plasma membrane nucleus cytoplasm cytosol Biological process negative regulation of interleukin-1 beta production negative regulation of epidermal growth factor receptor signaling pathway skin morphogenesis negative regulation of protein autophosphorylation cellular response to platelet-derived growth factor stimulus cellular response to dexamethasone stimulus cellular response to epidermal growth factor stimulus cellular hyperosmotic response negative regulation of epidermal growth factor-activated receptor activity negative regulation of peptidyl-tyrosine phosphorylation cellular response to insulin stimulus negative regulation of ERK1 and ERK2 cascade regulation of keratinocyte differentiation lung alveolus development lung vasculature development lung epithelium development regulation of type B pancreatic cell proliferation negative regulation of collagen biosynthetic process negative regulation of cardiac muscle hypertrophy in response to stress positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54206 74155 Ensembl ENSG00000116285 ENSMUSG00000028967 UniProt Q9UJM3 Q99JZ7 RefSeq (mRNA) NM_018948 NM_133753 NM_001356323 RefSeq (protein) NP_061821 NP_598514 NP_001343252 Location (UCSC) Chr 1: 8 – 8.03 Mb Chr 4: 150.94 – 150.95 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

MIG6 is a Cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000; Fiorentino et al., 2000).

Interactions

ERRFI1 has been shown to interact with Stratifin and CDC42.

Further reading

• Zhang YW, Vande Woude GF (March 2007). "Mig-6, signal transduction, stress response and cancer". Cell Cycle. 6 (5): 507–13. doi:10.4161/cc.6.5.3928. PMID 17351343.
• Wick M, Bürger C, Funk M, Müller R (August 1995). "Identification of a novel mitogen-inducible gene (mig-6): regulation during G1 progression and differentiation". Experimental Cell Research. 219 (2): 527–35. doi:10.1006/excr.1995.1261. PMID 7641805.
• Hackel PO, Gishizky M, Ullrich A (December 2001). "Mig-6 is a negative regulator of the epidermal growth factor receptor signal". Biological Chemistry. 382 (12): 1649–62. doi:10.1515/BC.2001.200. PMID 11843178. S2CID 23424592.
• Tsunoda T, Inokuchi J, Baba I, Okumura K, Naito S, Sasazuki T, Shirasawa S (October 2002). "A novel mechanism of nuclear factor kappaB activation through the binding between inhibitor of nuclear factor-kappaBalpha and the processed NH(2)-terminal region of Mig-6". Cancer Research. 62 (20): 5668–71. PMID 12384522.
• Saarikoski ST, Rivera SP, Hankinson O (October 2002). "Mitogen-inducible gene 6 (MIG-6), adipophilin and tuftelin are inducible by hypoxia". FEBS Letters. 530 (1–3): 186–90. doi:10.1016/S0014-5793(02)03475-0. PMID 12387890. S2CID 37181106.
• Anastasi S, Fiorentino L, Fiorini M, Fraioli R, Sala G, Castellani L, Alemà S, Alimandi M, Segatto O (July 2003). "Feedback inhibition by RALT controls signal output by the ErbB network". Oncogene. 22 (27): 4221–34. doi:10.1038/sj.onc.1206516. PMID 12833145. S2CID 26020025.
• Xu D, Makkinje A, Kyriakis JM (January 2005). "Gene 33 is an endogenous inhibitor of epidermal growth factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF function". The Journal of Biological Chemistry. 280 (4): 2924–33. doi:10.1074/jbc.M408907200. PMID 15556944.
• Keeton AB, Messina JL (April 2005). "Modulation of Elk-dependent-transcription by Gene33". Journal of Cellular Biochemistry. 94 (6): 1190–8. doi:10.1002/jcb.20370. PMID 15696545. S2CID 3023317.
• Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
• Anastasi S, Sala G, Huiping C, Caprini E, Russo G, Iacovelli S, Lucini F, Ingvarsson S, Segatto O (June 2005). "Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin". Oncogene. 24 (28): 4540–8. doi:10.1038/sj.onc.1208658. hdl:1946/21931. PMID 15856022.
• Ballarò C, Ceccarelli S, Tiveron C, Tatangelo L, Salvatore AM, Segatto O, Alemà S (August 2005). "Targeted expression of RALT in mouse skin inhibits epidermal growth factor receptor signalling and generates a Waved-like phenotype". EMBO Reports. 6 (8): 755–61. doi:10.1038/sj.embor.7400458. PMC 1369136. PMID 16007071.
• Zhang YW, Staal B, Su Y, Swiatek P, Zhao P, Cao B, Resau J, Sigler R, Bronson R, Vande Woude GF (January 2007). "Evidence that MIG-6 is a tumor-suppressor gene". Oncogene. 26 (2): 269–76. doi:10.1038/sj.onc.1209790. PMID 16819504.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9UJM3 (ERBB receptor feedback inhibitor 1) at the PDBe-KB.