EPC1

Enhancer of polycomb homolog 1 is a protein that in humans is encoded by the EPC1 gene.

EPC1
Identifiers
Aliases	EPC1, Epl1, enhancer of polycomb homolog 1
External IDs	OMIM: 610999; MGI: 1278322; HomoloGene: 32627; GeneCards: EPC1; OMA:EPC1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10p11.22 Start 32,267,751 bp End 32,378,798 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 A1 Start 6,435,951 bp End 6,516,108 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of colon bone marrow cells secondary oocyte pancreatic epithelial cell mucosa of ileum endothelial cell trabecular bone tibialis anterior muscle epithelium of lactiferous gland lactiferous duct Top expressed in Rostral migratory stream primary oocyte renal corpuscle medullary collecting duct cumulus cell fossa zygote conjunctival fornix condyle external carotid artery More reference expression data BioGPS n/a
Gene ontology Molecular function histone acetyltransferase activity protein binding Cellular component Piccolo NuA4 histone acetyltransferase complex nuclear membrane nucleus NuA4 histone acetyltransferase complex nucleoplasm Biological process vascular associated smooth muscle cell differentiation regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II histone H4 acetylation positive regulation of transcription by RNA polymerase II histone H2A acetylation regulation of transcription by RNA polymerase II positive regulation of transcription, DNA-templated transcription, DNA-templated regulation of growth negative regulation of gene expression, epigenetic negative regulation of transcription, DNA-templated negative regulation of G0 to G1 transition chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80314 13831 Ensembl ENSG00000120616 ENSMUSG00000024240 UniProt Q9H2F5 Q8C9X6 RefSeq (mRNA) NM_001272004 NM_001272019 NM_001282391 NM_025209 NM_001276350 NM_007935 NM_027497 RefSeq (protein) NP_001258933 NP_001258948 NP_001269320 NP_079485 NP_001263279 NP_031961 NP_081773 Location (UCSC) Chr 10: 32.27 – 32.38 Mb Chr 18: 6.44 – 6.52 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Doyon Y, Côté J (2004). "The highly conserved and multifunctional NuA4 HAT complex". Curr. Opin. Genet. Dev. 14 (2): 147–54. doi:10.1016/j.gde.2004.02.009. PMID 15196461.
• Liedtke W, Meyer G, Faustmann PM, et al. (1997). "Clonal expansion and decreased occurrence of peripheral blood gamma delta T cells of the V delta 2J delta 3 lineage in multiple sclerosis patients". Int. Immunol. 9 (7): 1031–41. doi:10.1093/intimm/9.7.1031. PMID 9237112.
• Wang X, Stollar BD (1999). "Immunoglobulin VH gene expression in human aging". Clin. Immunol. 93 (2): 132–42. doi:10.1006/clim.1999.4781. PMID 10527689.
• Kenny TP, Semrad TJ, Malyj W, Robbins DL (2001). "Mutational analysis of immunoglobulin germline derived Vlambda4B light chains in rheumatoid arthritis". Clin. Immunol. 99 (2): 283–90. doi:10.1006/clim.2001.5020. PMID 11318600.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cai Y, Jin J, Tomomori-Sato C, et al. (2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J. Biol. Chem. 278 (44): 42733–6. doi:10.1074/jbc.C300389200. PMID 12963728.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Doyon Y, Selleck W, Lane WS, et al. (2004). "Structural and Functional Conservation of the NuA4 Histone Acetyltransferase Complex from Yeast to Humans". Mol. Cell. Biol. 24 (5): 1884–96. doi:10.1128/MCB.24.5.1884-1896.2004. PMC 350560. PMID 14966270.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Attwooll C, Oddi S, Cartwright P, et al. (2005). "A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner". J. Biol. Chem. 280 (2): 1199–208. doi:10.1074/jbc.M412509200. PMID 15536069.
• Cai Y, Jin J, Florens L, et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes". J. Biol. Chem. 280 (14): 13665–70. doi:10.1074/jbc.M500001200. PMID 15647280.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Kee HJ, Kim JR, Nam KI, et al. (2007). "Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation". J. Biol. Chem. 282 (10): 7700–9. doi:10.1074/jbc.M611198200. PMID 17192267.