Elongin A is a protein that in humans is encoded by the ELOA gene.[5][6][7]

ELOA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesELOA, EloA, SIII, SIII p110, TCEB3A, TCEB3, transcription elongation factor B subunit 3, elongin A
External IDsOMIM: 600786; MGI: 1351315; HomoloGene: 37746; GeneCards: ELOA; OMA:ELOA - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003198

NM_013736

RefSeq (protein)

NP_003189

NP_038764

Location (UCSC)Chr 1: 23.74 – 23.76 MbChr 4: 135.73 – 135.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Elongin A is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis and is capable of forming a stable complex with elongins B and C. The von Hippel–Lindau tumor suppressor protein binds to elongins B and C and thereby inhibits transcription elongation.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000011007Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028668Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Aso T, Mokady N, Haque D, Conaway RC, Conaway JW (Mar 1996). "Assignment of a human gene encoding the 110-kDa subunit of general transcription factor elongin (SIII) to chromosome 1p36.1". Genomics. 30 (2): 393–4. PMID 8586449.
  6. ^ Aso T, Lane WS, Conaway JW, Conaway RC (Oct 1995). "Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II". Science. 269 (5229): 1439–43. Bibcode:1995Sci...269.1439A. doi:10.1126/science.7660129. PMID 7660129. S2CID 37649908.
  7. ^ a b "ELOA elongin A [ Homo sapiens (human) ]".

Further reading

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