ELK4

ETS domain-containing protein Elk-4 is a protein that in humans is encoded by the ELK4 gene.

ELK4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BC7, 1BC8, 1HBX, 1K6O
Identifiers
Aliases	ELK4, SAP1, ETS transcription factor, ETS transcription factor ELK4
External IDs	OMIM: 600246; MGI: 102853; HomoloGene: 1492; GeneCards: ELK4; OMA:ELK4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q32.1 Start 205,597,556 bp End 205,632,011 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 E4 Start 131,935,345 bp End 131,960,350 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii epithelium of colon sperm epithelium of nasopharynx skin of thigh skin of hip biceps brachii superficial temporal artery parietal pleura seminal vesicula Top expressed in saccule Paneth cell otic placode semi-lunar valve hair follicle aortic valve blood conjunctival fornix thymus ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding sequence-specific DNA binding chromatin binding transcription coregulator activity protein binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleoplasm nucleus cytosol Biological process histone H3 deacetylation cell differentiation regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2005 13714 Ensembl ENSG00000158711 ENSMUSG00000026436 UniProt P28324 P41158 RefSeq (mRNA) NM_001973 NM_021795 NM_007923 NM_001376954 NM_001376955 NM_001376956 NM_001376957 NM_001376958 NM_001376959 RefSeq (protein) NP_001964 NP_068567 NP_068567.1 NP_031949 NP_001363883 NP_001363884 NP_001363885 NP_001363886 NP_001363887 NP_001363888 Location (UCSC) Chr 1: 205.6 – 205.63 Mb Chr 1: 131.94 – 131.96 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene.

Interactions

ELK4 has been shown to interact with:

• BRCA1, and
• Serum response factor

Further reading

• Sharrocks AD, Brown AL, Ling Y, Yates PR (1998). "The ETS-domain transcription factor family". Int. J. Biochem. Cell Biol. 29 (12): 1371–87. doi:10.1016/S1357-2725(97)00086-1. PMID 9570133.
• Wasylyk B, Hagman J, Gutierrez-Hartmann A (1998). "Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway". Trends Biochem. Sci. 23 (6): 213–6. doi:10.1016/S0968-0004(98)01211-0. PMID 9644975.
• Dalton S, Treisman R (1992). "Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element". Cell. 68 (3): 597–612. doi:10.1016/0092-8674(92)90194-H. PMID 1339307. S2CID 26274460.
• Price MA, Rogers AE, Treisman R (1995). "Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET)". EMBO J. 14 (11): 2589–601. doi:10.1002/j.1460-2075.1995.tb07257.x. PMC 398373. PMID 7540136.
• Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
• Dalton S, Treisman R (1994). "Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element" (PDF). Cell. 76 (2): 411. PMID 8293474. Archived from the original (PDF) on 2011-09-28. Retrieved 2011-06-29.
• Janknecht R, Hunter T (1997). "Activation of the Sap-1a transcription factor by the c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase". J. Biol. Chem. 272 (7): 4219–24. doi:10.1074/jbc.272.7.4219. PMID 9020136.
• Janknecht R, Hunter T (1997). "Convergence of MAP kinase pathways on the ternary complex factor Sap-1a". EMBO J. 16 (7): 1620–7. doi:10.1093/emboj/16.7.1620. PMC 1169766. PMID 9130707.
• Stein B, Yang MX, Young DB, Janknecht R, Hunter T, Murray BW, Barbosa MS (1997). "p38-2, a novel mitogen-activated protein kinase with distinct properties". J. Biol. Chem. 272 (31): 19509–17. doi:10.1074/jbc.272.31.19509. PMID 9235954.
• Mo Y, Vaessen B, Johnston K, Marmorstein R (1998). "Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins". Mol. Cell. 2 (2): 201–12. doi:10.1016/S1097-2765(00)80130-6. PMID 9734357.
• Yates PR, Atherton GT, Deed RW, Norton JD, Sharrocks AD (1999). "Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors". EMBO J. 18 (4): 968–76. doi:10.1093/emboj/18.4.968. PMC 1171189. PMID 10022839.
• Kamakura S, Moriguchi T, Nishida E (1999). "Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus". J. Biol. Chem. 274 (37): 26563–71. doi:10.1074/jbc.274.37.26563. PMID 10473620.
• Chai Y, Chipitsyna G, Cui J, Liao B, Liu S, Aysola K, Yezdani M, Reddy ES, Rao VN (2001). "c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells". Oncogene. 20 (11): 1357–67. doi:10.1038/sj.onc.1204256. PMID 11313879.
• Hassler M, Richmond TJ (2001). "The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex". EMBO J. 20 (12): 3018–28. doi:10.1093/emboj/20.12.3018. PMC 150215. PMID 11406578.
• Mo Y, Ho W, Johnston K, Marmorstein R (2002). "Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex". J. Mol. Biol. 314 (3): 495–506. doi:10.1006/jmbi.2001.5138. PMID 11846562.

External links

• ELK4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook ELK4

This article incorporates text from the United States National Library of Medicine, which is in the public domain.