EIF5

Eukaryotic translation initiation factor 5 is a protein that in humans is encoded by the EIF5 gene.

EIF5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E9H, 2G2K, 2IU1
Identifiers
Aliases	EIF5, EIF-5, EIF-5A, eukaryotic translation initiation factor 5, Eukaryotic initiation factor 5
External IDs	OMIM: 601710; MGI: 95309; HomoloGene: 49610; GeneCards: EIF5; OMA:EIF5 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q32.32 Start 103,333,544 bp End 103,345,025 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12 F1|12 61.03 cM Start 111,504,450 bp End 111,513,186 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in postcentral gyrus pons sperm external globus pallidus lateral nuclear group of thalamus superior frontal gyrus pars compacta inferior olivary nucleus superior vestibular nucleus oocyte Top expressed in otic placode medullary collecting duct renal corpuscle saccule otic vesicle blood human fetus lacrimal gland tail of embryo spermatocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function translation initiation factor activity nucleotide binding translation factor activity, RNA binding GTP binding GTPase activity protein binding eukaryotic initiation factor eIF2 binding RNA binding cadherin binding GDP-dissociation inhibitor activity Cellular component nucleus plasma membrane cytoplasm cytosol Biological process regulation of translational initiation protein biosynthesis activation of GTPase activity formation of translation preinitiation complex translational initiation formation of cytoplasmic translation initiation complex Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1983 217869 Ensembl ENSG00000100664 ENSMUSG00000021282 UniProt P55010 P59325 RefSeq (mRNA) NM_183004 NM_001969 NM_173363 NM_178041 RefSeq (protein) NP_001960 NP_892116 NP_775539 NP_829887 Location (UCSC) Chr 14: 103.33 – 103.35 Mb Chr 12: 111.5 – 111.51 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

EIF5 is a GTPase-activating protein.

External links

• Cap-dependent translation initiation from Nature Reviews Microbiology. A good image and overview of the function of initiation factors
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Eukaryotic translation initiation factor 5 (EIF5)

Further reading

• Das S, Maiti T, Das K, Maitra U (1998). "Specific interaction of eukaryotic translation initiation factor 5 (eIF5) with the beta-subunit of eIF2". J. Biol. Chem. 272 (50): 31712–8. doi:10.1074/jbc.272.50.31712. PMID 9395514.
• Bandyopadhyay A, Maitra U (1999). "Cloning and characterization of the p42 subunit of mammalian translation initiation factor 3 (eIF3): demonstration that eIF3 interacts with eIF5 in mammalian cells". Nucleic Acids Res. 27 (5): 1331–7. doi:10.1093/nar/27.5.1331. PMC 148320. PMID 9973622.
• Das S, Maitra U (2000). "Mutational analysis of mammalian translation initiation factor 5 (eIF5): role of interaction between the beta subunit of eIF2 and eIF5 in eIF5 function in vitro and in vivo". Mol. Cell. Biol. 20 (11): 3942–50. doi:10.1128/MCB.20.11.3942-3950.2000. PMC 85746. PMID 10805737.
• Choi SK, Olsen DS, Roll-Mecak A, et al. (2000). "Physical and functional interaction between the eukaryotic orthologs of prokaryotic translation initiation factors IF1 and IF2". Mol. Cell. Biol. 20 (19): 7183–91. doi:10.1128/MCB.20.19.7183-7191.2000. PMC 86272. PMID 10982835.
• Das S, Ghosh R, Maitra U (2001). "Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein". J. Biol. Chem. 276 (9): 6720–6. doi:10.1074/jbc.M008863200. PMID 11092890.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Asano K, Shalev A, Phan L, et al. (2001). "Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation". EMBO J. 20 (9): 2326–37. doi:10.1093/emboj/20.9.2326. PMC 125443. PMID 11331597.
• Majumdar R, Bandyopadhyay A, Deng H, Maitra U (2002). "Phosphorylation of mammalian translation initiation factor 5 (eIF5) in vitro and in vivo". Nucleic Acids Res. 30 (5): 1154–62. doi:10.1093/nar/30.5.1154. PMC 101238. PMID 11861906.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Marintchev A, Kolupaeva VG, Pestova TV, Wagner G (2003). "Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 1535–40. Bibcode:2003PNAS..100.1535M. doi:10.1073/pnas.0437845100. PMC 149867. PMID 12569173.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Homma MK, Wada I, Suzuki T, et al. (2005). "CK2 phosphorylation of eukaryotic translation initiation factor 5 potentiates cell cycle progression". Proc. Natl. Acad. Sci. U.S.A. 102 (43): 15688–93. Bibcode:2005PNAS..10215688H. doi:10.1073/pnas.0506791102. PMC 1266118. PMID 16227438.
• Conte MR, Kelly G, Babon J, et al. (2006). "Structure of the eukaryotic initiation factor (eIF) 5 reveals a fold common to several translation factors". Biochemistry. 45 (14): 4550–8. doi:10.1021/bi052387u. PMID 16584190.
• Bieniossek C, Schütz P, Bumann M, et al. (2006). "The crystal structure of the carboxy-terminal domain of human translation initiation factor eIF5". J. Mol. Biol. 360 (2): 457–65. doi:10.1016/j.jmb.2006.05.021. PMID 16781736.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.