DTX2

Protein deltex-2 also known as E3 ubiquitin-protein ligase DTX2 is an enzyme that in humans is encoded by the DTX2 gene.

DTX2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1V87
Identifiers
Aliases	DTX2, RNF58, deltex 2, E3 ubiquitin ligase, deltex E3 ubiquitin ligase 2
External IDs	OMIM: 613141; MGI: 1921448; HomoloGene: 56904; GeneCards: DTX2; OMA:DTX2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q11.23 Start 76,461,676 bp End 76,505,995 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 G2 Start 136,023,654 bp End 136,061,726 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon olfactory zone of nasal mucosa sural nerve right testis minor salivary glands left testis blood skin of leg skin of abdomen vagina Top expressed in secondary oocyte primary oocyte zygote Rostral migratory stream condyle internal carotid artery fossa external carotid artery hair follicle motor neuron More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding protein binding metal ion binding transferase activity Cellular component cytoplasm nuclear membrane nucleus nucleoplasm Biological process Notch signaling pathway protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 113878 74198 Ensembl ENSG00000282379 ENSG00000091073 ENSMUSG00000004947 UniProt Q86UW9 Q8R3P2 RefSeq (mRNA) NM_001102594 NM_001102595 NM_001102596 NM_020892 NM_001256096 NM_001256097 NM_001256098 NM_023742 RefSeq (protein) NP_001096064 NP_001096065 NP_001096066 NP_065943 NP_001243025 NP_001243026 NP_001243027 NP_076231 Location (UCSC) Chr 7: 76.46 – 76.51 Mb Chr 5: 136.02 – 136.06 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

DTX2 functions as a ubiquitin E3 ligase in conjunction with the E2 enzyme UBCH5A.

Further reading

• Matsuno K, Diederich RJ, Go MJ, et al. (1995). "Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats". Development. 121 (8): 2633–44. doi:10.1242/dev.121.8.2633. PMID 7671825.
• Kishi N, Tang Z, Maeda Y, et al. (2001). "Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis". Int. J. Dev. Neurosci. 19 (1): 21–35. doi:10.1016/S0736-5748(00)00071-X. PMID 11226752. S2CID 21859491.
• Yamamoto N, Yamamoto S, Inagaki F, et al. (2002). "Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor". J. Biol. Chem. 276 (48): 45031–40. doi:10.1074/jbc.M105245200. PMID 11564735.
• Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.{{cite journal}}: CS1 maint: numeric names: authors list (link)
• Hiller M, Huse K, Szafranski K, et al. (2007). "Single-nucleotide polymorphisms in NAGNAG acceptors are highly predictive for variations of alternative splicing". Am. J. Hum. Genet. 78 (2): 291–302. doi:10.1086/500151. PMC 1380236. PMID 16400609.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Yi Z, Yi T, Wu Z (2007). "cDNA cloning, characterization and expression analysis of DTX2, a human WWE and RING-finger gene, in human embryos". DNA Seq. 17 (3): 175–80. doi:10.1080/10425170600857616. PMID 17286044. S2CID 26424595.

External links

• DTX2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.