Zinc finger protein ubi-d4 is a protein that in humans is encoded by the DPF2 gene.[5][6]

DPF2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDPF2, REQ, UBID4, ubi-d4, double PHD fingers 2, CSS7, SMARCG2
External IDsOMIM: 601671; MGI: 109529; HomoloGene: 21265; GeneCards: DPF2; OMA:DPF2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006268
NM_001330308

NM_001291078
NM_011262

RefSeq (protein)

NP_001317237
NP_006259
NP_006259.1

NP_001278007
NP_035392

Location (UCSC)Chr 11: 65.33 – 65.35 MbChr 19: 5.95 – 5.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000133884Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024826Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ninkina NN, Mertsalov IB, Kulikova DA, Alimova-Kost MV, Simonova OB, Korochkin LI, Kiselev SL, Buchman VL (Feb 2002). "Cerd4, third member of the d4 gene family: expression and organization of genomic locus". Mamm Genome. 12 (11): 862–6. doi:10.1007/s00335-001-3039-1. PMID 11845289. S2CID 2149578.
  6. ^ a b "Entrez Gene: DPF2 D4, zinc and double PHD fingers family 2".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.