DPF2

Zinc finger protein ubi-d4 is a protein that in humans is encoded by the DPF2 gene.

DPF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3IUF
Identifiers
Aliases	DPF2, REQ, UBID4, ubi-d4, double PHD fingers 2, CSS7, SMARCG2
External IDs	OMIM: 601671 MGI: 109529 HomoloGene: 21265 GeneCards: DPF2
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.1 Start 65,333,852 bp End 65,354,262 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19 A|19 4.34 cM Start 5,946,544 bp End 5,963,038 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte Achilles tendon ganglionic eminence canal of the cervix left uterine tube smooth muscle tissue right uterine tube popliteal artery gastric mucosa Top expressed in internal carotid artery external carotid artery primitive streak lens neural tube molar lip saccule thymus medial ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription corepressor activity histone acetyltransferase activity histone binding H3K9me3 modified histone binding lysine-acetylated histone binding Cellular component nucleus nucleoplasm intracellular membrane-bounded organelle centrosome cytoplasm cytosol histone acetyltransferase complex nBAF complex Biological process regulation of transcription, DNA-templated transcription, DNA-templated apoptotic signaling pathway apoptotic process negative regulation of transcription by RNA polymerase II chromatin organization nervous system development histone acetylation negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II negative regulation of myeloid progenitor cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5977 19708 Ensembl ENSG00000133884 ENSMUSG00000024826 UniProt Q92785 Q61103 RefSeq (mRNA) NM_006268 NM_001330308 NM_001291078 NM_011262 RefSeq (protein) NP_001317237 NP_006259 NP_006259.1 NP_001278007 NP_035392 Location (UCSC) Chr 11: 65.33 – 65.35 Mb Chr 19: 5.95 – 5.96 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors.

Further reading

• Gabig TG, Mantel PL, Rosli R, Crean CD (1994). "Requiem: a novel zinc finger gene essential for apoptosis in myeloid cells". J. Biol. Chem. 269 (47): 29515–9. doi:10.1016/S0021-9258(18)43910-5. PMID 7961935.
• Chestkov AV, Baka ID, Kost MV, et al. (1997). "The d4 gene family in the human genome". Genomics. 36 (1): 174–7. doi:10.1006/geno.1996.0440. PMID 8812431.
• Guru SC, Agarwal SK, Manickam P, et al. (1997). "A Transcript Map for the 2.8-Mb Region Containing the Multiple Endocrine Neoplasia Type 1 Locus". Genome Res. 7 (7): 725–35. doi:10.1101/gr.7.7.725. PMC 310681. PMID 9253601.
• Gabig TG, Crean CD, Klenk A, et al. (1998). "Expression and chromosomal localization of the Requiem gene". Mamm. Genome. 9 (8): 660–5. doi:10.1007/s003359900840. PMID 9680388. S2CID 22559464.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

External links

• DPF2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.