Disks large-associated protein 4 (DAP-4) also known as SAP90/PSD-95-associated protein 4 (SAPAP-4) is a protein that in humans is encoded by the DLGAP4 gene.[5][6]

DLGAP4
Identifiers
AliasesDLGAP4, DAP-4, DAP4, DLP4, SAPAP-4, SAPAP4, discs large homolog associated protein 4, DLG associated protein 4
External IDsOMIM: 616191; MGI: 2138865; HomoloGene: 8935; GeneCards: DLGAP4; OMA:DLGAP4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001042486
NM_014902
NM_183006
NM_001365621

NM_001042487
NM_001042488
NM_001277186
NM_001277187
NM_146128

RefSeq (protein)

NP_001035951
NP_055717
NP_892118
NP_001352550

NP_001035952
NP_001035953
NP_001264115
NP_001264116
NP_666240

Location (UCSC)Chr 20: 36.31 – 36.53 MbChr 2: 156.46 – 156.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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DAP-4 is a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. It is a signaling molecule that can interact with potassium channels and receptors, as well as other signaling molecules. DAP-4 can interact with PSD-95 through its guanylate kinase domain and may be involved in clustering PSD-95 in the postsynaptic density region. The encoded protein is one of at least four similar proteins that have been found. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000080845Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061689Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Takeuchi M, Hata Y, Hirao K, Toyoda A, Irie M, Takai Y (Jun 1997). "SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density". J Biol Chem. 272 (18): 11943–51. doi:10.1074/jbc.272.18.11943. PMID 9115257.
  6. ^ a b "Entrez Gene: DLGAP4 discs, large (Drosophila) homolog-associated protein 4".

Further reading

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