Diacylglycerol kinase zeta is an enzyme that in humans is encoded by the DGKZ gene.[5][6]

DGKZ
Identifiers
AliasesDGKZ, DAGK5, DAGK6, DGK-ZETA, hDGKzeta, diacylglycerol kinase zeta
External IDsOMIM: 601441; MGI: 1278339; HomoloGene: 37831; GeneCards: DGKZ; OMA:DGKZ - orthologs
EC number2.7.1.107
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001166597
NM_138306

RefSeq (protein)

NP_001160069
NP_612179

Location (UCSC)Chr 11: 46.33 – 46.38 MbChr 2: 91.76 – 91.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.[6]

Interactions

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DGKZ has been shown to interact with P110α.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000149091Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040479Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bunting M, Tang W, Zimmerman GA, McIntyre TM, Prescott SM (Jun 1996). "Molecular cloning and characterization of a novel human diacylglycerol kinase zeta". J Biol Chem. 271 (17): 10230–6. doi:10.1074/jbc.271.17.10230. PMID 8626588.
  6. ^ a b "Entrez Gene: DGKZ diacylglycerol kinase, zeta 104kDa".
  7. ^ Luo, Bai; Prescott Stephen M; Topham Matthew K (Oct 2003). "Protein kinase C alpha phosphorylates and negatively regulates diacylglycerol kinase zeta". J. Biol. Chem. 278 (41): 39542–7. doi:10.1074/jbc.M307153200. ISSN 0021-9258. PMID 12890670.

Further reading

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