DNA cross-link repair 1A protein is a protein that in humans is encoded by the DCLRE1A gene.[5][6][7]

DCLRE1A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDCLRE1A, PSO2, SNM1, SNM1A, DNA cross-link repair 1A
External IDsOMIM: 609682; MGI: 1930042; HomoloGene: 8920; GeneCards: DCLRE1A; OMA:DCLRE1A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001271816
NM_014881

NM_018831
NM_001360437
NM_001360438
NM_001360439

RefSeq (protein)

NP_001258745
NP_055696

n/a

Location (UCSC)Chr 10: 113.83 – 113.85 MbChr 19: 56.52 – 56.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1A is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000).[supplied by OMIM][7]

Function

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The protein DCLRE1A (DNA cross-link repair 1A) is also referred to as SNM1A (sensitive to nitrogen mustard 1A). DCLRE1A is a 5’ to 3’ exonuclease that forms a complex with the Cockayne syndrome B (CSB) protein. In this complex, CSB modulates the exonuclease activity of DCLRE1A and coordinates the efficient assembly of DCLRE1A to sites of DNA damage.[8] In human cells, this complex is recruited to DNA inter-strand cross-links, a form of DNA damage. The complex then participates in the repair of the cross-linked DNA. DCLRE1A protein is thought to be recruited by CSB to facilitate cross-link unhooking following incision 5’ to the cross-link by another complex, the ERCC1/XPF nuclease complex.[8] Failure of the DCLRE1A/CSB complex to carry out its repair function may contribute to the degenerative pathologies and premature aging features of Cockayne syndrome.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198924Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025077Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Demuth I, Digweed M (Nov 1998). "Genomic organization of a potential human DNA-crosslink repair gene, KIAA0086". Mutat Res. 409 (1): 11–6. doi:10.1016/s0921-8777(98)00037-8. PMID 9806498.
  6. ^ Hejna J, Philip S, Ott J, Faulkner C, Moses R (Oct 2007). "The hSNM1 protein is a DNA 5'-exonuclease". Nucleic Acids Res. 35 (18): 6115–23. doi:10.1093/nar/gkm530. PMC 2094091. PMID 17804464.
  7. ^ a b "Entrez Gene: DCLRE1A DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae)".
  8. ^ a b Iyama T, Lee SY, Berquist BR, Gileadi O, Bohr VA, Seidman MM, McHugh PJ, Wilson DM (2015). "CSB interacts with SNM1A and promotes DNA interstrand crosslink processing". Nucleic Acids Res. 43 (1): 247–58. doi:10.1093/nar/gku1279. PMC 4288174. PMID 25505141.

Further reading

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