DDB1- and CUL4-associated factor 11 also known as WD Repeat Domain 23 (WDR23) is a protein that in humans is encoded by the DCAF11 gene.

DCAF11
Identifiers
AliasesDCAF11, PRO2389, WDR23, GL014, DDB1 and CUL4 associated factor 11
External IDsOMIM: 613317; MGI: 90168; HomoloGene: 11886; GeneCards: DCAF11; OMA:DCAF11 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001163484
NM_025230
NM_181357

NM_001199009
NM_133734

RefSeq (protein)

NP_001156956
NP_079506
NP_852002

NP_001185938
NP_598495

Location (UCSC)Chr 14: 24.11 – 24.13 MbChr 14: 55.8 – 55.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


DCAF11 is a WD40 repeat protein, containing seven repeats of the closed circular solenoid protein domain WD40.[5] WDR-23 exists in two spatially distinct isoforms produced by alternative splicing, a cytoplasmic WDR-23A and nuclear WDR-23B. Nuclear and cytoplasmic versions of WDR-23 have distinct roles.[6]

References

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  1. ^ a b c ENSG00000284796 GRCh38: Ensembl release 89: ENSG00000100897, ENSG00000284796Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022214Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Choe KP, Przybysz AJ, Strange K (May 2009). "The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans". Molecular and Cellular Biology. 29 (10): 2704–2715. doi:10.1128/MCB.01811-08. PMC 2682033. PMID 19273594.
  6. ^ Spatola BN, Lo JY, Wang B, Curran SP (August 2019). "Nuclear and cytoplasmic WDR-23 isoforms mediate differential effects on GEN-1 and SKN-1 substrates". Scientific Reports. 9 (1): 11783. Bibcode:2019NatSR...911783S. doi:10.1038/s41598-019-48286-y. PMC 6692315. PMID 31409866.  This article incorporates text from this source, which is available under the CC BY 4.0 license.

Further reading

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