Lariat debranching enzyme is a protein that in humans is encoded by the DBR1 gene.[5][6]

DBR1
Identifiers
AliasesDBR1, debranching RNA lariats 1
External IDsOMIM: 607024; MGI: 1931520; HomoloGene: 9428; GeneCards: DBR1; OMA:DBR1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016216

NM_031403
NM_001368298

RefSeq (protein)

NP_057300

NP_113580
NP_001355227

Location (UCSC)Chr 3: 138.16 – 138.17 MbChr 9: 99.46 – 99.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The RNA lariat debranching enzyme, or DBR1, specifically hydrolyzes 2-prime-to-5-prime branched phosphodiester bonds at the branch point of excised lariat intron RNA and converts them into linear molecules.[supplied by OMIM][6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138231Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032469Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kim JW, Kim HC, Kim GM, Yang JM, Boeke JD, Nam K (Sep 2000). "Human RNA lariat debranching enzyme cDNA complements the phenotypes of Saccharomyces cerevisiae dbr1 and Schizosaccharomyces pombe dbr1 mutants". Nucleic Acids Res. 28 (18): 3666–73. doi:10.1093/nar/28.18.3666. PMC 110720. PMID 10982890.
  6. ^ a b "Entrez Gene: DBR1 debranching enzyme homolog 1 (S. cerevisiae)".

Further reading

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