DBC1

This article is about Deleted in bladder cancer protein 1. For breast cancer, see Deleted in Breast Cancer 1 (DBC1). For DBC 1 (radio station), see Digital Broadcasting Corporation (Hong Kong).

Deleted in bladder cancer protein 1 is a protein that in humans is encoded by the DBC1 gene.

BRINP1
Identifiers
Aliases	BRINP1, DBC1, DBCCR1, FAM5A, BMP/retinoic acid inducible neural specific 1
External IDs	OMIM: 602865 MGI: 1928478 HomoloGene: 8754 GeneCards: BRINP1
Gene location (Human) Chr. Chromosome 9 (human) Band 9q33.1 Start 119,153,458 bp End 119,369,435 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 C1 Start 68,679,751 bp End 68,872,634 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 23 entorhinal cortex postcentral gyrus superior frontal gyrus Brodmann area 46 prefrontal cortex frontal pole dorsolateral prefrontal cortex orbitofrontal cortex Top expressed in visual cortex superior frontal gyrus hippocampus proper piriform cortex prefrontal cortex primary motor cortex Region I of hippocampus proper barrel cortex temporal lobe medial dorsal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm neuronal cell body dendrite endoplasmic reticulum Biological process cell cycle negative regulation of cell cycle cell death behavioral fear response positive regulation of neuron differentiation negative regulation of neurogenesis social behavior cellular response to retinoic acid negative regulation of mitotic cell cycle short-term memory exploration behavior maternal behavior vocalization behavior Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1620 56710 Ensembl ENSG00000078725 ENSMUSG00000028351 UniProt O60477 Q920P3 RefSeq (mRNA) NM_014618 NM_019967 RefSeq (protein) NP_055433 NP_064351 Location (UCSC) Chr 9: 119.15 – 119.37 Mb Chr 4: 68.68 – 68.87 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene is located within chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in transitional cell carcinoma of the bladder. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers.

The functions of this gene are unknown, and it has not yet been placed in a protein family or functional pathway. Nonetheless, it is suspected to act as a tumor suppressor gene.

Further reading

• Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". Comptes Rendus de l'Académie des Sciences, Série III. 318 (2): 263–72. PMID 7757816.
• Habuchi T, Luscombe M, Elder PA, Knowles MA (1998). "Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33". Genomics. 48 (3): 277–88. doi:10.1006/geno.1997.5165. PMID 9545632.
• Nishiyama H, Takahashi T, Kakehi Y, et al. (2000). "Homozygous deletion at the 9q32-33 candidate tumor suppressor locus in primary human bladder cancer". Genes Chromosomes Cancer. 26 (2): 171–5. doi:10.1002/(SICI)1098-2264(199910)26:2<171::AID-GCC10>3.0.CO;2-B. PMID 10469456. S2CID 29396978.
• Nishiyama H, Gill JH, Pitt E, et al. (2001). "Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1". Oncogene. 20 (23): 2956–64. doi:10.1038/sj.onc.1204432. PMID 11420708. S2CID 3374427.
• Wright KO, Messing EM, Reeder JE (2002). "Increased expression of the acid sphingomyelinase-like protein ASML3a in bladder tumors". J. Urol. 168 (6): 2645–9. doi:10.1016/s0022-5347(05)64236-x. PMID 12442002.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wright KO, Messing EM, Reeder JE (2004). "DBCCR1 mediates death in cultured bladder tumor cells". Oncogene. 23 (1): 82–90. doi:10.1038/sj.onc.1206642. PMID 14712213. S2CID 3620390.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Beetz C, Brodoehl S, Patt S, et al. (2005). "Low expression but infrequent genomic loss of the putative tumour suppressor DBCCR1 in astrocytoma". Oncol. Rep. 13 (2): 335–40. doi:10.3892/or.13.2.335 (inactive 31 January 2024). PMID 15643521.{{cite journal}}: CS1 maint: DOI inactive as of January 2024 (link)
• Izumi H, Inoue J, Yokoi S, et al. (2005). "Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers". Hum. Mol. Genet. 14 (8): 997–1007. doi:10.1093/hmg/ddi092. PMID 15746151.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Louhelainen JP, Hurst CD, Pitt E, et al. (2006). "DBC1 re-expression alters the expression of multiple components of the plasminogen pathway". Oncogene. 25 (16): 2409–19. doi:10.1038/sj.onc.1209228. PMID 16369496. S2CID 3349365.