Death-associated protein kinase 2 is an enzyme that in humans is encoded by the DAPK2 gene.[5][6]

DAPK2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDAPK2, DRP-1, DRP1, death-associated protein kinase 2, death associated protein kinase 2
External IDsOMIM: 616567; MGI: 1341297; HomoloGene: 74940; GeneCards: DAPK2; OMA:DAPK2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_010019

RefSeq (protein)

NP_055141
NP_001350659

NP_034149
NP_001391612

Location (UCSC)Chr 15: 63.91 – 64.07 MbChr 9: 66.16 – 66.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Gene overexpression induces cell apoptosis. It uses multiple polyadenylation sites.[6]

The DAPK2 mRNA may undergo alternative splicing to produce a DAPK3-like encoding transcript.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000035664Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032380Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kawai T, Nomura F, Hoshino K, Copeland NG, Gilbert DJ, Jenkins NA, Akira S (Jun 1999). "Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity". Oncogene. 18 (23): 3471–80. doi:10.1038/sj.onc.1202701. PMID 10376525. S2CID 19035227.
  6. ^ a b "Entrez Gene: DAPK2 death-associated protein kinase 2".
  7. ^ Shoval Y, Berissi H, Kimchi A, Pietrokovski S (2011). "New Modularity of DAP-Kinases: Alternative Splicing of the DRP-1 Gene Produces a ZIPk-Like Isoform". PLOS ONE. 6 (2): e17344. Bibcode:2011PLoSO...617344S. doi:10.1371/journal.pone.0017344. PMC 3050894. PMID 21408167.

Further reading

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