D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase

D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase (EC 2.7.7.70, D-beta-D-heptose 7-phosphate kinase/D-beta-D-heptose 1-phosphate adenylyltransferase, D-glycero-D-manno-heptose-1beta-phosphate adenylyltransferase, hldE (gene), rfaE (gene)) is an enzyme with systematic name ATP:D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction

D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase
Identifiers
EC no.2.7.7.70
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins
D-glycero-beta-D-manno-heptose 1-phosphate + ATP ADP-D-glycero-beta-D-manno-heptose + diphosphate

The enzyme is involved in biosynthesis of ADP-L-glycero-beta-D-manno-heptose.

References

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  1. ^ Valvano MA, Marolda CL, Bittner M, Glaskin-Clay M, Simon TL, Klena JD (January 2000). "The rfaE gene from Escherichia coli encodes a bifunctional protein involved in biosynthesis of the lipopolysaccharide core precursor ADP-L-glycero-D-manno-heptose". Journal of Bacteriology. 182 (2): 488–97. doi:10.1128/jb.182.2.488-497.2000. PMC 94300. PMID 10629197.
  2. ^ Kneidinger B, Marolda C, Graninger M, Zamyatina A, McArthur F, Kosma P, Valvano MA, Messner P (January 2002). "Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli". Journal of Bacteriology. 184 (2): 363–9. doi:10.1128/jb.184.2.363-369.2002. PMC 139585. PMID 11751812.
  3. ^ Valvano MA, Messner P, Kosma P (July 2002). "Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides". Microbiology. 148 (Pt 7): 1979–89. doi:10.1099/00221287-148-7-1979. PMID 12101286.
  4. ^ Wang L, Huang H, Nguyen HH, Allen KN, Mariano PS, Dunaway-Mariano D (February 2010). "Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB)". Biochemistry. 49 (6): 1072–81. doi:10.1021/bi902018y. PMC 2844805. PMID 20050615.
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