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Cohorts for Heart and Aging Research in Genomic Epidemiology

Cohorts for Heart and Aging Research in Genomic Epidemiology, abbreviated CHARGE, is a consortium formed to facilitate meta-analyses of genome-wide association studies of aging and cardiovascular traits, and the replication of genotype–phenotype associations identified in such studies. CHARGE was initially launched in 2008 as a voluntary collaboration between five prospective cohort studies: the Age, Gene/Environment Susceptibility-Reykjavik Study (AGES) in Iceland, the Atherosclerosis Risk in Communities Study, the Cardiovascular Health Study, and the Framingham Heart Study in the United States, and the Rotterdam Study in the Netherlands. Other cohort studies have joined the consortium since its founding, including the Multi-Ethnic Study of Atherosclerosis and the Coronary Artery Risk Development in Young Adults Study.[1][2] The organization of the consortium consists of a Research Steering Committee, an Analysis Committee, a Genotyping Committee, and roughly 35 phenotype-specific working groups.[3]

References edit

  1. ^ Psaty, Bruce M.; O'Donnell, Christopher J.; Gudnason, Vilmundur; Lunetta, Kathryn L.; Folsom, Aaron R.; Rotter, Jerome I.; Uitterlinden, André G.; Harris, Tamara B.; Witteman, Jacqueline C.M. (February 2009). "Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Design of Prospective Meta-Analyses of Genome-Wide Association Studies From 5 Cohorts". Circulation: Cardiovascular Genetics. 2 (1): 73–80. doi:10.1161/CIRCGENETICS.108.829747. ISSN 1942-325X. PMC 2875693. PMID 20031568.
  2. ^ Psaty, Bruce M.; Sitlani, Colleen (May 2013). "The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium as a Model of Collaborative Science". Epidemiology. 24 (3): 346–348. doi:10.1097/EDE.0b013e31828b2cbb. ISSN 1044-3983. PMID 23549178. S2CID 38268179.
  3. ^ Austin, Melissa A.; Beaty, Terri H.; Dotson, W. David (2013). Genetic Epidemiology: Methods and Applications. CABI. p. 81. ISBN 9781780641812.

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