Clofibrate (trade name Atromid-S) is a lipid-lowering agent used for controlling the high cholesterol and triacylglyceride level in the blood. It belongs to the class of fibrates. It increases lipoprotein lipase activity to promote the conversion of VLDL to LDL, and hence reduce the level of VLDL. It can increase the level of HDL as well.
|AHFS/Drugs.com||Micromedex Detailed Consumer Information|
|Protein binding||Variable, 92–97% at therapeutic concentrations|
|Metabolism||Hydrolyzed to clofibric acid; hepatic glucuronidation|
|Elimination half-life||Highly variable; average 18–22 hours. Prolonged in renal failure|
|Excretion||Renal, 95 to 99%|
|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||242.698 g/mol g·mol−1|
|3D model (JSmol)|
|Boiling point||148 °C (298 °F)|
Complications and controversiesEdit
The World Health Organization Cooperative Trial on Primary Prevention of Ischaemic Heart Disease using clofibrate to lower serum cholesterol observed excess mortality in the clofibrate-treated group despite successful cholesterol lowering (47% more deaths during treatment with clofibrate and 5% after treatment with clofibrate) than the non-treated high cholesterol group. These deaths were due to a wide variety of causes other than heart disease, and remain "unexplained".
- Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 474. ISBN 9783527607495.
- "WHO cooperative trial on primary prevention of ischaemic heart disease with clofibrate to lower serum cholesterol: final mortality follow-up. Report of the Committee of Principal Investigators". Lancet. 2 (8403): 600–4. September 1984. doi:10.1016/s0140-6736(84)90595-6. PMID 6147641.
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